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D2R striatopallidal neurons inhibit both locomotor and drug reward processes

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      University of Zurich; de Kerchove d'Exaerde, A
    • الموضوع:
      2008
    • نبذة مختصرة :
      The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
      Journal Article
      Research Support, Non-U.S. Gov't
      info:eu-repo/semantics/published
    • File Description:
      1 full-text file(s): application/pdf
    • ISSN:
      1546-1726
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....67b510471af75b03393fdb7ec05bf595