Contributors: Yaman, Yontem; Ozdilli, Kursat; Elli, Murat; Anak, Sema Medipol Univ, Dept Pediat Hematol & Oncol, Fac Med, Goztepe Mahallesi 2309,Sk 6, TR-34214 Istanbul, Turkey; Baysoy, Gokhan Medipol Univ, Dept Pediat Gastroenterol, Med Fac, Istanbul, Turkey; Kelesoglu, Emre Medipol Univ, Dept Pediat, Med Fac, Istanbul, Turkey; Cakir, Asli Medipol Univ, Dept Pathol, Med Fac, Istanbul, Turkey; Genc, Dildar Bahar Sisli Etfal Hamidiye Training & Res Hosp, Dept Pediat Hematol & Oncol, Istanbul, Turkey
نبذة مختصرة : WOS: 000463814000008 PubMed ID: 31061639 In the pediatric population, hematopoietic stem cell transplantation (HSCT) is used to treat a wide variety of diseases, both malignant and nonmalignant. For many of these diseases, HSCT is a well-established treatment. Acute graft-versus-host disease (GVHD) continues to be a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Graft versus host disease is a common complication of allo-SCT which is induced by donor T cell recognition of recipient alloantigens. The occurrence of autologous GVHD suggests that inappropriate recognition of host self-antigens may occur. GVHD in patients who received autologous HSCT is extremely rare compared to patients who received allogeneic HSCT. We present the case of a 4-year-old girl with metastatic neuroblastoma who spontaneously developed autologous GVHD after autologous HSCT.
No Comments.