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Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Medical Research Council (MRC); Wellcome Trust
    • بيانات النشر:
      Springer Science and Business Media LLC, 2018.
    • الموضوع:
      2018
    • نبذة مختصرة :
      Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.
    • ISSN:
      1546-170X
      1078-8956
    • الرقم المعرف:
      10.1038/s41591-018-0056-0
    • Rights:
      Springer TDM
      implied-oa
    • الرقم المعرف:
      edsair.doi.dedup.....5021bf34c256db614d40425843c7ac3f