Intrauterine administration of platelet‐rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single‐arm self‐controlled trial

Purpose The purpose of this study was to investigate the effectiveness of intrauterine administration of platelet‐rich plasma (PRP) in frozen embryo transfer (FET) cycle in Japanese patients with a thin endometrium. Method A prospective single‐arm self‐controlled trial was conducted in Japan. PRP administration was performed in 36 of the 39 eligible patients with a thin endometrium (≤7 mm). Hormone replacement therapy (HRT) with estrogen was performed for 2 menstrual cycles, and PRP was administrated on the 10th and 12th days of the second HRT cycle. The endometrial thickness was evaluated on transvaginal ultrasonography by two physicians at every visit, one an attending physician and the other a specialist physician blinded to the date and timing of the sonography. FET was performed during the second HRT cycle after PRP administration. Results After PRP administration, the mean (SD) endometrial thickness on the 14th day was significantly increased by 1.27 mm (P
It is the first report to show that PRP improved endometrial thickness improving possible pregnancy rate in infertile patients from Japan. As a new approach, we have tried to exclude measurement bias by the attending physician, by measuring endometrial thickness independently by the other physician who is blind to the date and timing of sonography.