miRNAsas biomarkers for diagnosis of type 2 diabetes: A systematic review

This systematic review summarizes results of studies that evaluated the expression of microRNAs (miRs) in prediabetes or type 2 diabetes (T2D).The information was obtained from PubMed, EMBL-EBI, Wanfang, Trip Database, Lilacs, CINAHL, Human microRNA Disease Database (HMDD) v3.0, and Google. A qualitative synthesis of the results was performed and miRs frequency was graphically represented. From 1893 identified studies, only 55 fulfilled the inclusion criteria. These 55 studies analyzed miRs in T2D, and of them, 13 also described data of prediabetes.In diabetics, 122 miRs were reported and 35 miRs for prediabetics. However, we identified that five miRs (-122-5p, 144-3p, 210, 375, and -126b) were reported more often in diabetics and four (144-3p, -192, 29a, and -30d) in prediabetics.Circulating miRs could be used as biomarkers of T2D. However, it is necessary to validate these microRNAs in prospective and multicenter studies with different population subgroups, considering age, gender, and risk factors.背景: 本文系统综述了糖尿病前期或2型糖尿病(T2D)中评估microRNAs(miRs)表达的研究结果。 方法: 应用计算机检索PubMed、EMBL-EBI、万方、Trip数据库、Lilacs、CINAHL、人类microRNA疾病数据库(HMDD)v3.0和Google。对结果进行了定性汇总, 并用图形表示了miRs频率。自1893年确定的研究以来, 只有55项符合纳入标准。这55项研究分析了T2D的miRs, 其中13项也描述了糖尿病前期的数据。 结果: 在糖尿病中报告了122个miRs, 糖尿病前期患者中报告了35个miRs。然而, 我们发现5个miRs(-122-5p、144-3p、210、375和-126b)在糖尿病患者中更常见, 而4个miRs(144-3p、-192、29a和-30d)在糖尿病前期患者中被报道得更多。 结论: 循环miRs可作为T2D的生物标志物。考虑到年龄、性别和危险因素, 有必要在不同人群亚组的前瞻性和多中心研究中验证这些microRNAs。.