نبذة مختصرة : Awake craniotomy is the technique of choice for the patients with lesions on eloquent cortical areas. It is still challenging for anesthesiologists, especially in cases where the patient’s general condition is poor or with a relatively inexperienced surgeon. Occasionally the inability to control airway can lead to complications such as airway obstruction or hypercarbia, which can lead to brain bulging. Different anesthetic combinations have been reported for awake craniotomy. Nevertheless, there is still no consensus about the optimal regimen for awake craniotomy [1]. We experienced six patients with fronto-temporal lesion who needed awake surgery to preserve eloquent areas. Two patients had cardiac problems and one patient had chronic depression (Table 1). All patients received scalp nerve block with 0.75% ropivacaine and 1 : 200,000 epinephrine. Three of the patients under went “asleep-awake” technique using a laryngeal mask airway (LMA). The other patients received moderate to mild sedation. We used propofol and remifentanil infusion for sedation and two patients received dexmedetomidine infusion as an adjuvant. We did not use muscle relaxants in any cases. Mean operation time was 323 minutes and estimated blood loss was 380 ml. One patient with severe snoring refused sedation at first and stayed fully awake until the end of cortical mapping. This patient displayed marked agitation during the awake period. Therefore, we started low dose propofol-remifentanil infusion after cortical mapping and the patient underwent intermittent apnea and hypercarbia (Patient 1). Most of the patients were maintained in a sedated state during the procedures and responded properly during cortical mapping. Two patients with LMA awakened 20-30 min after stopping infusion (Patients 2 and 3), and one (Patient 3) showed moderate hypercarbia. Other patients awakened within 10 min after stopping infusion. Surgeons were satisfied with patient’s brain condition and response. One patient (Patient 5) with moderate sedation experienced extreme fear during the procedure. Others replied that it was endurable. Awake craniotomy is very stressful surgery to patients. Although it is not always consistent, there is a greater possibility of extreme fear in the patients with prior anxiety history (e.g., Patient 5). Patients with medical problems, especially with cardiovascular diseases, may not tolerate the stressful environment and may lead to hemodynamic instability. In such cases, deep sedation is preferred. According to other references, most painful procedures were head pin fixation, manipulating dura, and closure after operation. Patients can easily get stressed during these procedures despite successful scalp nerve block [2]. Therefore, maintaining deep sedation or general anesthetic status during these procedures would be more helpful for patients’ comfort. The most important problem of deep sedation is respiratory depression, and using airway device such as LMA may be a good choice [3]. But, it can also cause delayed awake and some residual effects with dull response or respiratory depression after extubation (e.g., Patients 2 and 3). Hypercarbia brings increased intracranial pressure in spite of normal oxygen saturation, and it can make the surgery harder. Yet, in practice, LMA re-insertion after neurologic test is very dangerous owing to head fixation posture.
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