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Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

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  • معلومة اضافية
    • Contributors:
      Génomique évolutive des Microbes / Microbial Evolutionary Genomics; Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS); Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB; Centers for Disease Control and Prevention [Atlanta] (CDC); Centers for Disease Control and Prevention; University of Melbourne; Wisconsin State Laboratory of Hygiene [Madison] (WSLH); University of Wisconsin-Madison; Collection de l'Institut Pasteur (CIP); Institut Pasteur [Paris] (IP); Pasteur International Bioresources network (PIBNet); Plateforme de Microbiologie Mutualisée (PIBnet) - Mutualized Platform for Microbiology (P2M); Prévention et Thérapie Moléculaires des Maladies humaines; This work was supported by Institut Pasteur, French government’s Investissement d’Avenir program Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (grant ANR-10-LABX-62-IBEID), and the Advanced Molecular Detection (AMD) initiative at CDC. O.R. was supported by a fellowship from Fondation pour la Recherche Médicale (grant number ARF20150934077). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.; We thank D. Mornico of Institut Pasteur and V. Nyak of CDC for assistance with submission of sequence data to public repositories. We would also like to thank the State Health Departments of Michigan and Illinois for contributing strains and information for the cases outside of the State of Wisconsin. The efforts of laboratory staff in both DHQP and DHCPP are greatly appreciated.; ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010); Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS); Institut Pasteur [Paris]
    • بيانات النشر:
      Springer Science and Business Media LLC, 2017.
    • الموضوع:
      2017
    • نبذة مختصرة :
      An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics are revealed, and their last common ancestor existed approximately one year before the first recognized human infection. Unlike other E. anophelis, the outbreak strain had a disrupted DNA repair mutY gene caused by insertion of an integrative and conjugative element. This genomic change probably contributed to the high evolutionary rate of the outbreak strain and may have increased its adaptability, as many mutations in protein-coding genes occurred during the outbreak. This unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides a dramatic example of the potential impact of pathogen evolutionary dynamics on infectious disease epidemiology.
    • File Description:
      application/pdf
    • ISSN:
      2041-1723
    • الرقم المعرف:
      10.1038/ncomms15483
    • Rights:
      CC BY
    • الرقم المعرف:
      edsair.doi.dedup.....388f0ec134246821adb103d8517e092c