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Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      American Association for Cancer Research (AACR), 2023.
    • الموضوع:
      2023
    • نبذة مختصرة :
      Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid–liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.
    • ISSN:
      1538-7445
      0008-5472
    • الرقم المعرف:
      10.1158/0008-5472.can-22-3631
    • Rights:
      CC BY NC ND
      URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
    • الرقم المعرف:
      edsair.doi.dedup.....37232f99454241925fa3bc10c6fbdab0