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A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Abad, José Luís; Fabriàs, Gemma; Abad, José Luís [0000-0002-8343-9611]; Fabriàs, Gemma [0000-0001-7162-3772]
    • بيانات النشر:
      American Chemical Society, 2020.
    • الموضوع:
      2020
    • نبذة مختصرة :
      The synthesis of a series of vinylated analogues of sphingosine-1-phosphate together with their unambiguous configurational assignment by VCD methods is reported. Among them, compound RBM10-8 can irreversibly inhibit human sphingosine-1-phosphate lyase (hS1PL) while behaving also as an enzyme substrate. These findings, together with the postulated mechanism for S1PL activity, reinforce the role of RBM10-8 as a new mechanism-based hS1PL inhibitor. Copyright © 2019 American Chemical Society.
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....36440eea6ba4da213345455ef8e2d2b1