Improving obesity and lipid metabolism using conjugated linoleic acid

Conjugated linoleic acid (CLA) can prevent fatty acid accumulation induced by a high-fructose diet and improve lipid metabolism disorders in patients.We aimed to investigate the effect of CLA on obesity and lipid metabolism and its possible mechanism.Eight-month-old male BKS.Cg-Dock7CLA treatment notably reduced the dietary and water intake of db/db mice, effectively reduced body weight, and decreased serum TG and TC levels (p 0.05). Increased expression of PPARα (p 0.05) and decreased expression of CD36 (p 0.001) were observed in the liver of mice that were fed CLA. CLA increased PPARα expression (p 0.001) and decreased PPARγ (p 0.001) and CD36 expression (p 0.01) in HepG2 cells.Our results showed that CLA can improve lipid metabolism in obese mice through upregulation of PPARα expression and downregulation of CD36 expression.