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Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

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  • معلومة اضافية
    • Contributors:
      European Commission; Epidemiology; Erasmus MC other; Pediatrics; Internal Medicine; Epidemiology and Data Science; ACS - Atherosclerosis & ischemic syndromes; APH - Aging & Later Life; APH - Global Health; APH - Health Behaviors & Chronic Diseases; APH - Personalized Medicine; ARD - Amsterdam Reproduction and Development; APH - Methodology; AGEM - Amsterdam Gastroenterology Endocrinology Metabolism; ACS - Amsterdam Cardiovascular Sciences; Public and occupational health; Erasmus University Medical Center [Rotterdam] (Erasmus MC); Children’s Hospital of Philadelphia (CHOP ); Herlev and Gentofte Hospital; Manchester Academic Health Science Centre (MAHSC); University of Manchester [Manchester]; University of Kuopio; University of Copenhagen = Københavns Universitet (KU); Universität Leipzig [Leipzig]; University Medical Center Groningen [Groningen] (UMCG); University of Bristol [Bristol]; Université d'Oulu; The Wellcome Trust Centre for Human Genetics [Oxford]; University of Oxford [Oxford]; Vrije Universiteit Brussel (VUB); CIBER de Epidemiología y Salud Pública (CIBERESP); Helmholtz-Zentrum München (HZM); University of Newcastle [Australia] (UoN); Turku University Hospital (TYKS); Statens Serum Institut [Copenhagen]; Sahlgrenska Academy at University of Gothenburg [Göteborg]; Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP); Queen Mary University of London (QMUL); Norwegian Institute of Public Health [Oslo] (NIPH); King‘s College London; University of Groningen [Groningen]; University of Amsterdam [Amsterdam] (UvA); Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)); Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); University of Cambridge [UK] (CAM); McMaster University [Hamilton, Ontario]; University of Exeter; Ludwig-Maximilians-Universität München (LMU); University of the Basque Country [Bizkaia] (UPV/EHU); The Wellcome Trust Sanger Institute [Cambridge]; The University of Western Australia (UWA); Nutrition et obésités: approches systémiques (nutriomics) (UMR-S 1269 INSERM - Sorbonne Université); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Universitat Rovira i Virgili; Imperial College London; University of Helsinki; Vrije Universiteit Amsterdam [Amsterdam] (VU); University College of London [London] (UCL); University of Bergen (UiB); University of Tampere [Finland]; University of Oulu; Copenhagen University Hospital; University of Turku; University of Queensland [Brisbane]; Haukeland University Hospital; Università degli Studi di Milano-Bicocca [Milano] (UNIMIB); National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust University College London Wellcome 090532106130098381203141212259WT206194United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)U01DK105535National Institute for Health Research (NIHR)NF-SI-0617-10090Netherlands Organization for Health Research and DevelopmentTOP 40-00812-9811010American Diabetes Association1-17-PDF-077Daniel B. Burke Chair for Diabetes Research United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USAR01 HD058886Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR)2017 FI_B 00636Generalitat de Catalunya -Fons Social Europeu European Research Council Advanced Grant META-GROWTH (ERC-2012-AdG) 322605Oak Foundation Fellowship Wellcome TrustEuropean CommissionWT104150098497/Z/12/ZRoyal Society of LondonEuropean CommissionWT104150Wellcome Trust098395/Z/12/ZNatural Resources CanadaCanadian Forest ServiceCanada Research Chairs Finnish Cultural Foundation KNAW Academy Professor Award PAH/6635TARGET Danish Diabetes Academy Copenhagen Graduate School of Health and Medical Sciences Netherlands Organization for Health Research and Development (VIDI) 016.136.361European Research Council (ERC)European Commission648916European Research Council (ERC)European Commission UK Research & Innovation (UKRI)Medical Research Council UK (MRC)European CommissionMRC_MC_UU_12012/5MC_UU_00011/1National Institute for Health Research (NIHR) Botnar Foundation Bernard Wolfe Health Neuroscience Endowment European Community's Seventh Framework Programme (FP7/2007-2013) project Beta-JUDO 279153University of Bristol UK Research & Innovation (UKRI)Medical Research Council UK (MRC)MC_UU_00011/1MC_UU_00011/3French National Agency of Research, F-CRIN/FORCE; Clinicum; Johan Eriksson / Principal Investigator; Department of General Practice and Primary Health Care; Helsinki University Hospital Area; Genomics of Sex Differences; Institute for Molecular Medicine Finland; Centre of Excellence in Complex Disease Genetics; Elisabeth Ingrid Maria Widen / Principal Investigator; Genomic Discoveries and Clinical Translation; University of Copenhagen = Københavns Universitet (UCPH); Universität Leipzig; University of Oxford; Helmholtz Zentrum München = German Research Center for Environmental Health; University of Newcastle [Callaghan, Australia] (UoN); Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)); Institut Pasteur de Lille; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS); Conservatoire National des Arts et Métiers [CNAM] (CNAM); HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU); Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics); Helsingin yliopisto = Helsingfors universitet = University of Helsinki; Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB); Felix, Janine F [0000-0002-9801-5774]; Apollo - University of Cambridge Repository; Biological Psychology; APH - Mental Health; Felix, Janine F. [0000-0002-9801-5774]; Tampere University; Tampere University Hospital Catchment Area; Department of Clinical Physiology and Nuclear Medicine; Clinical Medicine; Department of Clinical Chemistry; Groningen Research Institute for Asthma and COPD (GRIAC); Public Health Research (PHR); Life Course Epidemiology (LCE); Vogelezang, Suzanne; Bradfield, Jonathan P; Ahluwalia, Tarunveer S; Curtin, John A; Hyppönen, Elina; Felix, JF; Early Growth Genetics Consortium
    • بيانات النشر:
      PUBLIC LIBRARY SCIENCE, 2020.
    • الموضوع:
      2020
    • نبذة مختصرة :
      The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R(g)ranging from 0.11 to 0.76, P-values
      CP received funding from the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London. MMcC is a Wellcome Senior Investigator and an NIHR Senior Investigator. MMcC received funding from Wellcome (090532, 106130, 098381, 203141, 212259), NIDDK (U01DK105535), and NIHR (NF-SI-0617-10090). TGMV was supported by ZonMW (TOP 40-00812-9811010). DLC was supported by the American Diabetes Association Grant 1-17-PDF-077. SFAG is supported by the Daniel B. Burke Chair for Diabetes Research and NIH Grant R01 HD058886. NVT is funded by a pre-doctoral grant from the Agencia de Gestio d'Ajuts Universitaris i de Recerca (2017 FI_B 00636), Generalitat de Catalunya -Fons Social Europeu. BK received personal funding from the European Research Council Advanced Grant META-GROWTH (ERC-2012-AdG -no. 322605). BF was supported by an Oak Foundation Fellowship. RMF and RNB are supported by Sir Henry Dale Fellowship (Wellcome Trust and Royal Society grant: WT104150). ATH is supported by a Wellcome Trust Senior Investigator award (grant number 098395/Z/12/Z). DM is supported by a Canada Research Chair. DLC was supported by the American Diabetes Association Grant 1-17-PDF077. JTL was supported by the Finnish Cultural Foundation. DIB received a KNAW Academy Professor Award (PAH/6635). MH received PhD scholarship funding from TARGET (http://target.ku.dk), The Danish Diabetes Academy (http://danishdiabetesacademy.dk) and the Copenhagen Graduate School of Health and Medical Sciences. VWVJ received funding from the Netherlands Organization for Health Research and Development (VIDI 016.136.361) and the European Research Council (ERC-2014-CoG-648916). ISF was supported by the European Research Council, Wellcome Trust (098497/Z/12/Z), Medical Research Council (MRC_MC_UU_12012/5), the NIHR Cambridge Biomedical Research Centre, the Botnar Foundation, the Bernard Wolfe Health Neuroscience Endowment and the European Community's Seventh Framework Programme (FP7/2007-2013) project Beta-JUDO n degrees 279153. IB acknowledges funding from Wellcome (WT206194). ES works in a unit that receives funding from the University of Bristol and the UK Medical Research Council (MC_UU_00011/1, MC_UU_00011/3). GDS works in the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council (MC_UU_00011/1). KC received funds from the French National Agency of Research, F-CRIN/FORCE. All funding for the studies that provided the underlying data for this manuscript can be found in S1 Text. The funders had no role in study design, data collection and analysis, data interpretation, decision to publish, or preparation of the manuscript.
    • File Description:
      application/pdf; text/xml; application/zip; fulltext
    • ISSN:
      1553-7404
      1553-7390
    • الرقم المعرف:
      10.1371/journal.pgen.1008718
    • الرقم المعرف:
      10.1371/journal.pgen.1008718⟩
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....2f7e3e9c63ac8faa6aa819187732da43