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Induction of Apoptosis by Matrine Derivative ZS17 in Human Hepatocellular Carcinoma BEL-7402 and HepG2 Cells through ROS-JNK-P53 Signalling Pathway Activation

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Multidisciplinary Digital Publishing Institute, 2022.
    • الموضوع:
      2022
    • نبذة مختصرة :
      Hepatocellular carcinoma (HCC) is one of the most common malignancies and ranks third among cancer-related deaths worldwide. Using matrine as a lead compound, 12 matrine derivatives were designed and synthesised, and their antiproliferative activities were evaluated in four cancer cell lines. Eight of the twelve compounds showed strong antiproliferative activity, with an IC50 of
    • File Description:
      application/pdf
    • ISSN:
      1422-0067
    • الرقم المعرف:
      10.3390/ijms232415991
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....18c89683d271d0880bf984f9cd8d82b6