Is there a rationale for heparin use among severe COVID-19 patients?

The International Society on Thrombosis and Haemostasis (ISTH) has proposed a new category to detect the earlier phase of sepsis-associated disseminated intravascular coagulation (DIC), called sepsis-induced coagulopathy. The criteria included platelet count, prothrombin time and Sequential Organ Failure Assessment (SOFA) score.() Patients with sepsis and extensive forms of DIC may develop overt thromboembolic complications, or clinically less apparent microvascular clot formation that may contribute to multiple organ failure.() Activation of the vascular endothelium, platelets, and leukocytes results in dysregulated thrombin [...]