Potenci��lne nov�� markery predikcie komplik��cii a priebehu ochorenia Covid-19 / New potential markers for predicting the complications and course of Covid-19

{"references":["Aggarwal, S., Gollapudi, S. a Gupta, S. (1999) \"Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases\", Journal of immunology (Baltimore, Md.: 1950), 162(4), p. 2154–2161. Dostupné na: https://pubmed.ncbi.nlm.nih.gov/9973490/ (Accessed: September 10, 2021).","Ahmed, O. (2019) \"CAR-T-cell neurotoxicity: hope is on the horizon\", Blood, 133(20), p. 2114–2116. doi:10.1182/blood-2019-03-900985.","Alay, H. a Laloglu, E. (2021) \"The role of angiopoietin‐2 and surfactant protein‐D levels in SARS‐CoV‐2‐related lung injury: A prospective, observational, cohort study\", Journal of Medical Virology, 93(10), p. 6008-6015. doi:10.1002/jmv.27184.","Audo, A. et al. (2020) \"Acute Pulmonary Embolism in SARS-CoV-2 Infection Treated With Surgical Embolectomy\", The Annals of thoracic surgery, 110(5), p. e403–e404. doi:10.1016/J.ATHORACSUR.2020.04.013.","Bairwa, M. et al. (2021) \"Hematological profile and biochemical markers of COVID-19 non-survivors: A retrospective analysis\", Clinical Epidemiology and Global Health, 11, p. 100770. doi:10.1016/J.CEGH.2021.100770.","Becher, B., Tugues, S. a Greter, M. (2016) \"GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation\", Immunity, 45(5), p. 963–973. doi:10.1016/j.immuni.2016.10.026.","Bhandari, V. et al. (2006) \"Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death\", Nature Medicine 2006 12:11, 12(11), p. 1286–1293. doi:10.1038/nm1494.","Calfee, C. S. et al. (2008) \"Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury\", Intensive Care Medicine 2008 35:2, 35(2), p. 248–257. doi:10.1007/S00134-008-1235-0.","Calfee, C. S. et al. (2012) \"Plasma angiopoietin-2 in clinical acute lung injury: Prognostic and pathogenetic significance\", Critical Care Medicine, 40(6), p. 1731–1737. doi:10.1097/CCM.0B013E3182451C87.","Carubbi, F. et al. (2021) \"Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 units\", Scientific Reports, 11(1), 4863. doi:10.1038/s41598-021-83831-8.","Channappanavar, R. a Perlman, S. (2017) \"Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology\", Seminars in Immunopathology, 39(5), p. 529. doi:10.1007/S00281-017-0629-X.","Chen, R. et al. (2020) \"Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China\", The Journal of Allergy and Clinical Immunology, 146(1), p. 89. doi:10.1016/J.JACI.2020.05.003.","Clinical Spectrum | COVID-19 Treatment Guidelines (no date). Available at: https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/ (Accessed: October 11, 2021).","Dai, X. M. et al. (2002) \"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects\", Blood, 99(1), p. 111–120. doi:10.1182/BLOOD.V99.1.111.","D'Ardes, D. et al. (2020) \"COVID-19 and RAS: Unravelling an Unclear Relationship\", International Journal of Molecular Sciences, 21(8), 3003. doi:10.3390/IJMS21083003.","Gattinoni, L., Chiumello, D. a Rossi, S. (2020) \"COVID-19 pneumonia: ARDS or not?\", Critical Care 2020 24:1, 24(1), p. 1–3. doi:10.1186/S13054-020-02880-Z.","Ghati, A. et al. (2021) \"Exogenous pulmonary surfactant: A review focused on adjunctive therapy for severe acute respiratory syndrome coronavirus 2 including SP-A and SP-D as added clinical marker\", Current Opinion in Colloid & Interface Science, 51, p. 101413. doi:10.1016/j.cocis.2020.101413.","Giamarellos-Bourboulis, E. J. et al. (2020) \"Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure\", Cell Host & Microbe, 27(6), p. 992–1000. doi:10.1016/J.CHOM.2020.04.009.","Gómez-Pastora, J. et al. (2020) \"Hyperferritinemia in critically ill COVID-19 patients – Is ferritin the product of inflammation or a pathogenic mediator?\", Clinica Chimica Acta, 509, p. 249–251. doi:10.1016/j.cca.2020.06.033.","Greter, M. et al. (2012) \"GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells\", Immunity, 36(6), p. 1031–1046. doi:10.1016/j.immuni.2012.03.027.","Guilliams, M. et al. (2013) \"Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF\", The Journal of experimental medicine, 210(10), p. 1977–1992. doi:10.1084/jem.20131199.","Hamilton, J. A. (2020) \"GM-CSF in inflammation\", The Journal of experimental medicine, 217(1). doi:10.1084/jem.20190945.","Hamilton, J. A., Cook, A.D. a Tak, P.P. (2016) \"Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases\", Nature reviews. Drug discovery, 16(1), p. 53–70. doi:10.1038/nrd.2016.231.","Han, H. et al. (2020) \"Prominent changes in blood coagulation of patients with SARS-CoV-2 infection\", Clinical chemistry and laboratory medicine, 58(7), p. 1116–1120. doi:10.1515/CCLM-2020-0188.","Helms, J. et al. (2020) \"High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study\", Intensive care medicine, 46(6), p. 1089–1098. doi:10.1007/S00134-020-06062-X.","Henry, B. M. et al. (2020) \"Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis\", Clinical Chemistry and Laboratory Medicine (CCLM), 58(7), p. 1021–1028. doi:10.1515/CCLM-2020-0369.","Hou, H. et al. (2020) \"Using IL‐2R/lymphocytes for predicting the clinical progression of patients with COVID‐19\", Clinical and Experimental Immunology, 201(1), p. 76. doi:10.1111/CEI.13450.","Hu, R. et al. (2020) \"Procalcitonin levels in COVID-19 patients\", International Journal of Antimicrobial Agents, 56(2), p. 106051. doi:10.1016/J.IJANTIMICAG.2020.106051.","Huang, I. a Pranata, R. (2020) \"Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis\", Journal of Intensive Care, 8(1), p. 36. doi:10.1186/S40560-020-00453-4.","Huang, Z. et al. (2020) \"Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis\", The American journal of emergency medicine, 38(3), p. 641–647. doi:10.1016/J.AJEM.2019.10.023.","Iba, T. et al. (2020) \"Coagulopathy in COVID-19\", Journal of thrombosis and haemostasis : JTH, 18(9), p. 2103–2109. doi:10.1111/jth.14975.","Islam, H. et al. (2021) \"Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action?\", Frontiers in Immunology, 12. doi:10.3389/fimmu.2021.677008.","Lang, F. M. et al. (2020) \"GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches\", Nature Reviews Immunology, 20(8), p. 507-514. doi:10.1038/s41577-020-0357-7.","Lauw, F. et al. (2000) \"Proinflammatory effects of IL-10 during human endotoxemia\", Journal of immunology (Baltimore, Md. : 1950), 165(5), p. 2783–2789. doi:10.4049/JIMMUNOL.165.5.2783.","Leisman, D. E. et al. (2020) \"Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes\", The Lancet Respiratory Medicine, 8(12), p. 1233–1244. doi:10.1016/S2213-2600(20)30404-5.","Levi, M. et al. (2020) \"Coagulation abnormalities and thrombosis in patients with COVID-19\", The Lancet. Haematology, 7(6), p. e438–e440. doi:10.1016/S2352-3026(20)30145-9.","Li, H. et al. (2020) \"SARS-CoV-2 and viral sepsis: observations and hypotheses\", Lancet (London, England), 395(10235), p. 1517. doi:10.1016/S0140-6736(20)30920-X.","Lieschke, G. J. et al. (1994) \"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization\", Blood, 84(6), 1737–1746.","Lippi, G. a Cervellin, G. (2018) \"Procalcitonin for diagnosing and monitoring bacterial infections: for or against?\", Clinical Chemistry and Laboratory Medicine (CCLM), 56(8), p. 1193–1195. doi:10.1515/CCLM-2018-0312.","Liu, T. et al. (2020) \"The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019\", EMBO Molecular Medicine, 12(7). doi:10.15252/EMMM.202012421.","Lu, L. et al. (2021) \"A Potential Role of Interleukin 10 in COVID-19 Pathogenesis\", Trends in Immunology, 42(1), p. 3. doi:10.1016/J.IT.2020.10.012.","Matute-Bello, G. et al. (1997) \"Neutrophil apoptosis in the acute respiratory distress syndrome\", American journal of respiratory and critical care medicine, 156(6), p. 1969–1977. doi:10.1164/ajrccm.156.6.96-12081.","McGonagle, D. et al. (2020) \"Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia\", The Lancet. Rheumatology, 2(7), p. e437–e445. doi:10.1016/S2665-9913(20)30121-1.","Melbye, H. et al. (2004) \"The course of C-reactive protein response in untreated upper respiratory tract infection\", The British Journal of General Practice, 54(506), p. 653. Available at: /pmc/articles/PMC1326064/ (Accessed: October 6, 2021).","Nicholls, J. M. et al. (2003) \"Lung pathology of fatal severe acute respiratory syndrome\", Lancet (London, England), 361(9371), p. 1773. doi:10.1016/S0140-6736(03)13413-7.","Pan, C. et al. (2020) \"Lung Recruitability in COVID-19–associated Acute Respiratory Distress Syndrome: A Single-Center Observational Study\", https://doi.org/10.1164/rccm.202003-0527LE, 201(10), p. 1294–1297. doi:10.1164/RCCM.202003-0527LE.","Parikh, S. M. et al. (2006) \"Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans\", PLOS Medicine, 3(3), p. e46. doi:10.1371/JOURNAL.PMED.0030046.","Polimeni, A. et al. (2021) \"Differences in coagulopathy indices in patients with severe versus non-severe COVID-19: a meta-analysis of 35 studies and 6427 patients\", Scientific Reports, 11(1), p. 10464. doi:10.1038/s41598-021-89967-x.","Reghunathan, R. et al. (2005) \"Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome\", BMC immunology, 6(2). doi:10.1186/1471-2172-6-2.","Robba, C. et al. (2020) \"Multiple organ dysfunction in SARS-CoV-2: MODS-CoV-2\", Expert Review of Respiratory Medicine, 14(9), 865–868. doi:10.1080/17476348.2020.1778470.","Schmal, H. et al. (1998) \"Soluble ICAM-1 activates lung macrophages and enhances lung injury\", Journal of immunology (Baltimore, Md.: 1950), 161(7), p. 3685–3693.","Singh, S., Sharma, A. a Arora, S.K. (2014) \"High Producer Haplotype (CAG) of -863C/A, -308G/A and -238G/A Polymorphisms in the Promoter Region of TNF-α Gene Associate with Enhanced Apoptosis of Lymphocytes in HIV-1 Subtype C Infected Individuals from North India\", PLoS ONE, 9(5), e98020. doi:10.1371/JOURNAL.PONE.0098020.","Sorensen, G. L. (2018) \"Surfactant Protein D in Respiratory and Non-Respiratory Diseases\", Frontiers in Medicine, 5. doi:10.3389/fmed.2018.00018.","Spadaro, S. et al. (2021) \"Markers of endothelial and epithelial pulmonary injury in mechanically ventilated COVID-19 ICU patients\", Critical Care 2021 25:1, 25(1), p. 1–9. doi:10.1186/S13054-021-03499-4.","Stanley, E. et al. (1994) \"Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology\", Proceedings of the National Academy of Sciences of the United States of America, 91(12), p. 5592–5596. doi:10.1073/pnas.91.12.5592.","Tan, C. et al. (2020) \"C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early\", Journal of Medical Virology, 92(7), p. 856–862. doi:10.1002/JMV.25871.","Tan, L. et al. (2020) \"Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study\", Signal Transduction and Targeted Therapy, 5(1). doi:10.1038/S41392-020-0148-4.","Tang, N. et al. (2020) \"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia\", Journal of thrombosis and haemostasis : JTH, 18(4), p. 844–847. doi:10.1111/JTH.14768.","Terpos, E. et al. (2020) \"Hematological findings and complications of COVID‐19\", American Journal of Hematology, 95(7), p. 834–847. doi:10.1002/AJH.25829.","Thwaites, R. S. et al. (2021) \"Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19\", Science Immunology, 6(57). doi:10.1126/sciimmunol.abg9873.","Tong, M. et al. (2021) \"Serum surfactant protein D in COVID-19 is elevated and correlated with disease severity\", BMC Infectious Diseases, 21(1), p. 737. doi:10.1186/s12879-021-06447-3.","Trapnell, B. C., Whitsett, J.A. a Nakata, K. (2003) \"Pulmonary Alveolar Proteinosis\", New England Journal of Medicine, 349(26), p. 2527–2539. doi:10.1056/NEJMra023226.","Unkel, B. et al. (2012) \"Alveolar epithelial cells orchestrate DC function in murine viral pneumonia\", The Journal of clinical investigation, 122(10), p. 3652–3664. doi:10.1172/JCI62139.","Urra, J. M. et al. (2020) \"Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients\", Clinical Immunology (Orlando, Fla.), 217, p. 108486. doi:10.1016/J.CLIM.2020.108486.","Vaduganathan, M. et al. (2020) \"Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19\", The New England journal of medicine, 382(17), p. 1653–1659. doi:10.1056/NEJMSR2005760.","Wang, L. (2020) \"C-reactive protein levels in the early stage of COVID-19\", Médecine et Maladies Infectieuses, 50(4), p. 332–334. doi:10.1016/J.MEDMAL.2020.03.007.","Ware, L. B. et al. (2013) \"Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome\", Critical Care, 17(5). doi:10.1186/cc13080.","Wiktor-Jedrzejczak, W. et al. (1990) \"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse\", Proceedings of the National Academy of Sciences of the United States of America, 87(12), p. 4828–4832. doi:10.1073/PNAS.87.12.4828.","Wool, G. D. a Miller, J. L. (2021) \"The Impact of COVID-19 Disease on Platelets and Coagulation\", Pathobiology, 88(1), p. 15–27. doi:10.1159/000512007.","Xu, H. et al. (2020) \"High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa\", International Journal of Oral Science, 12(1). doi:10.1038/S41368-020-0074-X.","Yang, A. P. et al. (2020) \"The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients\", International Immunopharmacology, 84. doi:10.1016/j.intimp.2020.106504.","Zhou, P. et al. (2020) \"A pneumonia outbreak associated with a new coronavirus of probable bat origin\", Nature, 579(7798), p. 270. doi:10.1038/S41586-020-2012-7.","Zou, X. et al. (2020) \"Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection\", Frontiers of medicine, 14(2), p. 185–192. doi:10.1007/s11684-020-0754-0."]}
S��HRN Bilancia ��udsk��ch ��ivotov straten��ch po��as pand��mie COVID-19 vo svete je zna��n��, ke����e k 2.11. 2021 prekro��il celosvetovo po��et ��mrt�� 5 mili��nov. K tomu treba e��te pripo����ta�� n��klady na zv����en�� mieru chudoby, naru��enie pracovn��ho a s��kromn��ho ��ivota, rast��ce soci��lne nepokoje, potrebu rie��i�� n��rast psychologick��ch probl��mov det�� aj dospel��ch, prevenciu a lie��bu z��va��n��ch diagn��z (onkologick��, kardiovaskul��rne, metabolick�� a in��), ktor�� boli kv��li pand��mii ods��van��. V��asn�� a presn�� laborat��rna diagnostika ochorenia COVID-19 zohr��va v��znamn�� ��lohu pri spoma��ovan�� a kontrolovan�� pand��mie. Po potvrden�� pr��tomnosti SARS-CoV-2 v��rusu v organizme sa u symptomatick��ch pacientov sleduj�� viacer�� hematologick�� a z��palov�� markery poukazuj��ce na z��va��nos�� klinick��ho stavu pacienta. Neust��le sa v��ak vyh��ad��vaj�� a testuj�� nov�� vhodn�� biochemick�� markery hlavne na predikciu priebehu ochorenia s cie��om maxim��lne zn����i�� mortalitu sp��soben�� touto v��rusovou infekciou, ale z��rove�� aj posilni�� glob��lnu pripravenos�� a schopnos�� lep��ie reagova�� na podobn�� situ��cie v bud��cnosti. ABSTRACT The balance of human lives lost during the COVID-19 pandemic is significant, as more than 5 million people have died (by November 2021), in addition to the costs of increased poverty, disruption of work and private life and growing social unrest. Early and accurate laboratory diagnosis of Covid-19 plays an important role in slowing down and controlling the pandemics. After confirmation of the presence of the SARS-CoV-2 virus in the human body, there are several hematological and inflammation markers monitored in symptomatologic patients, which can indicate severity of the clinical state of the patient. However, new suitable biochemical markers are constantly being sought and tested, mainly to predict the course of the disease in order to minimize mortality caused by this viral infection, but also to strengthen global preparedness and ability to respond better to similar situations in the future.