Stereoselective Synthesis of Protected Peptides Containing an anti β‐Hydroxy Tyrosine

Protected peptides containing an anti β‐hydroxy tyrosine are synthesized in a straightforward and highly efficient manner through the direct and stereoselective addition of N‐azidoacetyl‐4‐isopropyl‐1,3‐thiazolidine‐2‐thione to dialkyl acetals catalyzed by a nickel(II) complex, the forging of an amide bond by removal of the chiral auxiliary with an amino ester, and final coupling with a third amino acid.