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Infection by Tubercular Mycobacteria Is Spread by Nonlytic Ejection from Their Amoeba Hosts

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  • معلومة اضافية
    • بيانات النشر:
      American Association for the Advancement of Science (AAAS), 2009.
    • الموضوع:
      2009
    • نبذة مختصرة :
      To generate efficient vaccines and cures for Mycobacterium tuberculosis , we need a far better understanding of its modes of infection, persistence, and spreading. Host cell entry and the establishment of a replication niche are well understood, but little is known about how tubercular mycobacteria exit host cells and disseminate the infection. Using the social amoeba Dictyostelium as a genetically tractable host for pathogenic mycobacteria, we discovered that M. tuberculosis and M. marinum , but not M. avium , are ejected from the cell through an actin-based structure, the ejectosome. This conserved nonlytic spreading mechanism requires a cytoskeleton regulator from the host and an intact mycobacterial ESX-1 secretion system. This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells.
    • ISSN:
      1095-9203
      0036-8075
    • الرقم المعرف:
      10.1126/science.1169381
    • الرقم المعرف:
      edsair.doi.dedup.....1119ea9fae400d1563b8e1f76193bd22