Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Attaching Zanamivir to a Polymer Markedly Enhances Its Activity Against Drug-resistant Strains of Influenza a Virus

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemistry; Koch Institute for Integrative Cancer Research at MIT; Klibanov, Alexander M.; Weight, Alisha Kessel; Haldar, Jayanta; Cienfuegos, Luis Álvarez de; Chen, Jianzhu
    • بيانات النشر:
      Elsevier BV, 2011.
    • الموضوع:
      2011
    • نبذة مختصرة :
      Effects of the commercial drug zanamivir (Relenza™) covalently attached to poly-l-glutamine on the infectivity of influenza A viruses are examined using the plaque reduction assay and binding affinity to viral neuraminidase (NA). These multivalent drug conjugates exhibit (i) up to a 20,000-fold improvement in anti-influenza potency compared with the zanamivir parent against human and avian viral strains, including both wild-type and drug-resistant mutants, and (ii) superior neuraminidase (NA) inhibition constants, especially for the mutants. These findings provide a basis for exploring polymer-attached inhibitors as more efficacious therapeutics, particularly against drug-resistant influenza strains.
      National Institutes of Health (U.S.) (Grant Number U01-AI074443)
      Fundación Ramón Areces. Postdoctoral Fellowship
    • File Description:
      application/pdf
    • ISSN:
      0022-3549
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....0d362c49af28a0c1287a9d3214d63eb4