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Two tales: Worldwide distribution of Central Asian (CAS) versus ancestral East-African Indian (EAI) lineages of Mycobacterium tuberculosis underlines a remarkable cleavage for phylogeographical, epidemiological and demographical characteristics

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  • معلومة اضافية
    • Contributors:
      Unité de la Tuberculose et des Mycobactéries - WHO Supranational TB Reference Laboratory; Institut Pasteur de la Guadeloupe; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO); DC was awarded a Ph.D. fellowship by the European Social Funds through the Regional Council of Guadeloupe, while the work done at Institut Pasteur de la Guadeloupe was supported by a FEDER grant, financed by the European Union and Guadeloupe Region (Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020, Grant number 2015-FED-192).; The authors are highly grateful to various contributors who very kindly provided genotyping data to the previous versions of the database, from SpolDB1 (1999) to SpolDB4 (2006), and more recently to the SITVITWEB (2012) as well as the SITVIT2 (2018) and SITVITEXTEND (upcoming) databases.; European Project: 2015-FED-192,FEDER-Guadeloupe
    • بيانات النشر:
      Public Library of Science, 2019.
    • الموضوع:
      2019
    • نبذة مختصرة :
      International audience; The East African Indian (EAI) and Central Asian (CAS) lineages of Mycobacterium tuberculosis complex (MTBC) mainly infect tuberculosis (TB) patients in the eastern hemisphere which contains many of the 22 high TB burden countries including China and India. We investigated if phylogeographical, epidemiological and demographical characteristics for these 2 lineages differed in SITVIT2 database. Genotyping results and associated data (age, sex, HIV serology, drug resistance) on EAI and CAS lineages (n = 10,974 strains) were extracted. Phylogenetic and Bayesian, and other statistical analyses were used to compare isolates. The male/female sex ratio was 907/433 (2.09) for the EAI group vs. 881/544 (1.62) for CAS (p-value
    • File Description:
      application/pdf
    • ISSN:
      1932-6203
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi.dedup.....04b3698a3b745fead062983b16c94283