Usefulness of thyrogastric immune features as predictors of pernicious anaemia that lacks intrinsic factor antibody

Summary Introduction: The study aims to evaluate the diagnostic utility of thyrogastric immune features in the identification of intrinsic factor antibody negative (IFA −ve) pernicious anaemia (PA) patients. Methods: Clinico-pathological features of ‘intrinsic factor antibody positive (IFA +ve) PA’ and ‘IFA −ve presumed PA’ Chinese patients in a single hospital (2001–2009) were studied. Coefficients of independent variables identified were used as weighted scores. The result was validated by patients (1994–2000) with Schilling test done. Results: Comparison of 127 ‘IFA +ve PA’ and 130 ‘IFA −ve presumed PA’ patients showed four independent variables, namely (+) gastric parietal cell (GPC) antibody (OR, 2.907, 95%; CI, 2.346–3.468; P