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Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Wiley, 2011.
    • الموضوع:
      2011
    • نبذة مختصرة :
      4. These results demonstrate that in hPMVEC, hypoxia decreased CAT-2 expression, L-arg uptake and NO production. Furthermore, the hypoxia-induced decrease in NO production in hPMVEC can be attenuated by overexpressing CAT in these cells. We speculate that the CAT may represent a novel therapeutic target for treating pulmonary hypertensive disorders.
    • ISSN:
      0305-1870
    • الرقم المعرف:
      10.1111/j.1440-1681.2011.05609.x
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi...........7770200d16c441e97eddb1eae9f56733