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Antagonism of the interleukin 4 receptor α promotes T H 1‐signalling among T cells from patients with atopic dermatitis after stimulation

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  • معلومة اضافية
    • بيانات النشر:
      Wiley, 2019.
    • الموضوع:
      2019
    • نبذة مختصرة :
      Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease. Molecular characterization of AD shows an underlying inflammation with tissue infiltration of T helper (TH ) 2 cells and increased IL-4 and IL-13. The multifaceted roles of IL-4 and IL-13 in allergic disease development make IL-4Rα an attractive target for treatment strategies, and a neutralizing monoclonal antibody which antagonizes the effects of both IL-4 and IL-13 by blocking the interaction site found in the IL-4 receptor subunit α (IL-4Rα) has been successfully used to treat patients with moderate-to-severe AD. To elucidate the effects of IL-4Rα blockade on the cellular level, we used flow cytometry to examine cytokine production after antigen stimulation in human T cells from patients with AD (n = 12) and healthy controls (n = 6). The cells were stimulated with and without a neutralizing monoclonal antibody against IL-4Rα. Our results indicate that blocking IL-4Rα prohibits IL-4 signalling and IL-13 signalling and thereby TH 2 differentiation followed by an upregulation of interferon-γ-producing cells.
    • ISSN:
      1365-3083
      0300-9475
    • الرقم المعرف:
      10.1111/sji.12835
    • Rights:
      OPEN
    • الرقم المعرف:
      edsair.doi...........135a8f30f116daf3a4d10030e7cd1e27