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Historical Perspective on Mitochondrial Medicine

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: DiMauro, Salvatore; Garone, Caterina
  • اللغة:
    English
  • المصدر:
    Developmental Disabilities Research Reviews. Jun 2010 16(2):106-113.
  • الوصف المادي :
    PDF
  • الموضوع:
    2010
  • نوع التسجيلة:
    Journal Articles
    Reports - Evaluative
  • معلومة اضافية
    • Peer Reviewed:
      Y
    • المصدر:
      8
    • الموضوع:
      History; Medicine; Biochemistry; Genetics; Molecular Structure; Genetic Disorders; Biomedicine; Diseases; Research
    • الرقم المعرف:
      10.1002/ddrr.102
    • ISSN:
      1940-5510
    • نبذة مختصرة :
      In this review, we trace the origins and follow the development of mitochondrial medicine from the premolecular era (1962-1988) based on clinical clues, muscle morphology, and biochemistry into the molecular era that started in 1988 and is still advancing at a brisk pace. We have tried to stress conceptual advances, such as endosymbiosis, uniparental inheritance, intergenomic signaling and its defects, and mitochondrial dynamics. We hope that this historical review also provides an update on mitochondrial medicine, although we fully realize that the speed of progress in this area makes any such endeavor akin to writing on water.
    • نبذة مختصرة :
      As Provided
    • Number of References:
      38
    • الموضوع:
      2010
    • الرقم المعرف:
      EJ899518