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Pilot Study of Respiratory-Swallow Coordination in Amyotrophic Lateral Sclerosis

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  • المؤلفون: Garand, Kendrea L. (ORCID Garand, Kendrea L. (ORCID 0000-0003-0758-4398); Bhutada, Ankita M. (ORCID Bhutada, Ankita M. (ORCID 0000-0003-4918-5176); Hopkins-Rossabi, Theresa (ORCID Hopkins-Rossabi, Theresa (ORCID 0000-0003-0494-0457); Mulekar, Madhuri S. (ORCID Mulekar, Madhuri S. (ORCID 0000-0001-8659-728X); Carnaby, Giselle (ORCID Carnaby, Giselle (ORCID 0000-0002-3724-2818)
  • اللغة:
    English
  • المصدر:
    Journal of Speech, Language, and Hearing Research. Aug 2022 65(8):2815-2828.
  • الموضوع:
    2022
  • نوع التسجيلة:
    Journal Articles
    Reports - Research
  • معلومة اضافية
    • Availability:
      American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
    • Peer Reviewed:
      Y
    • المصدر:
      14
    • الموضوع:
      Neurological Impairments; Motor Reactions; Physical Disabilities; Physiology; Adults; Psychomotor Skills
    • الرقم المعرف:
      10.1044/2022_JSLHR-21-00619
    • ISSN:
      1092-4388
      1558-9102
    • نبذة مختصرة :
      Purpose: Amyotrophic lateral sclerosis (ALS) impacts bulbar and respiratory musculature, which may contribute to impaired swallow function (dysphagia) and respiratory-swallow coordination. The purpose of this pilot study was to examine if respiratory-swallow coordination in individuals with ALS was perturbed compared to healthy controls. We further explored relationships between measures of respiratory function and self-reported swallowing outcomes on respiratory-swallow coordination. Method: We employed a cross-sectional design with eight participants with ALS and eight age- and sex-matched healthy participants. Respiratory inductance plethysmography and a nasal cannula were used to capture respiratory-swallow phase patterns during a standardized clinical swallow examination. The advantageous respiratory-swallow phase pattern was defined if exhalation surrounded the swallow (E-E). Spirometry was used to capture indices of respiratory function (forced vital capacity % predicted, peak cough flow [PCF]). Validated questionnaires were used to collect information regarding ALS-related bulbar functional status and swallowing-related concerns. Results: Compared to the matched healthy cohort, individuals with ALS demonstrated higher rates of non-E-E respiratory-swallow phase patterning and worse bulbar/swallow dysfunction. Group (ALS), swallow tasks, and PCF were significantly associated with respiratory-swallow phase pattern. Conclusions: These preliminary findings support altered respiratory-swallow phase patterning in ALS. Future work should employ an instrumental assessment to quantify swallowing physiology and elucidate the relationship between perturbed respiratory-swallow coordination and swallowing function.
    • نبذة مختصرة :
      As Provided
    • الموضوع:
      2023
    • الرقم المعرف:
      EJ1360736