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Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Burian, Alexis N.; Zhao, Wufan; Lo, Te-Wen (ORCID Lo, Te-Wen (ORCID 0000-0002-1231-5531); Thurtle-Schmidt, Deborah M. (ORCID Thurtle-Schmidt, Deborah M. (ORCID 0000-0002-9747-9585)
  • اللغة:
    English
  • المصدر:
    Biochemistry and Molecular Biology Education. Sep-Oct 2021 49(5):815-825.
  • الموضوع:
    2021
  • نوع التسجيلة:
    Journal Articles
    Reports - Descriptive
    Guides - Classroom - Teacher
  • معلومة اضافية
    • Peer Reviewed:
      Y
    • المصدر:
      11
    • Intended Audience:
      Teachers
    • الموضوع:
      Genetics; Science Instruction; Teaching Methods; Biology; Statistical Analysis; Medicine; Data Analysis; Ethics; Social Problems; Scientific Research; Case Studies; Guides
    • الرقم المعرف:
      10.1002/bmb.21561
    • ISSN:
      1470-8175
    • نبذة مختصرة :
      To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called "-omics," have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated, including anticipatory guides and discussion questions for active engagement in the classroom. Additionally, the Supporting Information includes a case study to apply technical and ethical concepts from the text.
    • نبذة مختصرة :
      As Provided
    • الموضوع:
      2021
    • الرقم المعرف:
      EJ1310247