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Using COVID-19 as a Teaching Tool in a Time of Remote Learning: A Workflow for Bioinformatic Approaches to Identifying Candidates for Therapeutic and Vaccine Development

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Bryce, Samantha (ORCID Bryce, Samantha (ORCID 0000-0002-3444-7252); Heath, Kevin N.; Issi, Luca; Ryder, Elizabeth F.; Rao, Reeta (ORCID Rao, Reeta (ORCID 0000-0001-7936-9617)
  • اللغة:
    English
  • المصدر:
    Biochemistry and Molecular Biology Education. Sep-Oct 2020 48(5):492-498.
  • الموضوع:
    2020
  • نوع التسجيلة:
    Journal Articles
    Reports - Descriptive
  • معلومة اضافية
    • Availability:
      Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
    • Peer Reviewed:
      Y
    • المصدر:
      7
    • Sponsoring Agency:
      National Center for Complementary and Integrative Health (NCCIH) (DHHS/NIH)
      National Science Foundation (NSF)
    • Contract Number:
      1R15AT00992601
      1742446
    • Intended Audience:
      Teachers
    • Education Level:
      Higher Education
      Postsecondary Education
    • الموضوع:
      COVID-19; Pandemics; Distance Education; Science Instruction; Teaching Methods; Biology; Information Science; Biological Sciences; Majors (Students); College Students; Computer Software; Scientific Research; Inquiry; Therapy; Immunization Programs; Critical Thinking; Problem Solving
    • الرقم المعرف:
      10.1002/bmb.21413
    • ISSN:
      1470-8175
    • نبذة مختصرة :
      The COVID-19 pandemic has led to an urgent need for engaging computational alternatives to traditional laboratory exercises. Here we introduce a customizable and flexible workflow, designed with the SARS CoV-2 virus that causes COVID-19 in mind, as a means of reinforcing fundamental biology concepts using bioinformatics approaches. This workflow is accessible to a wide range of students in life science majors regardless of their prior bioinformatics knowledge, and all software is freely available, thus eliminating potential cost barriers. Using the workflow can thus provide a diverse group of students the opportunity to conduct inquiry-driven research. Here we demonstrate the utility of this workflow and outline the logical steps involved in the identification of therapeutic or vaccine targets against SARS CoV-2. We also provide an example of how the workflow may be adapted to other infectious microbes. Overall, our workflow anchors student understanding of viral biology and genomics and allows students to develop valuable bioinformatics expertise as well as to hone critical thinking and problem-solving skills, while also creating an opportunity to better understand emerging information surrounding the COVID-19 pandemic.
    • نبذة مختصرة :
      As Provided
    • الموضوع:
      2020
    • الرقم المعرف:
      EJ1270004