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Impact of Adolescent Obesity on Middle-Age Health of Women Given Data MAR

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  • معلومة اضافية
    • Peer Reviewed:
      Y
    • المصدر:
      31
    • Sponsoring Agency:
      National Institutes of Health (DHHS)
      Institute of Education Sciences (ED)
    • Contract Number:
      R01AG048801
      UL1TR002649
      R305D130033
    • الموضوع:
      Obesity; Adolescents; Adults; Females; Correlation; Body Composition; Body Weight; Body Height; Physiology; Aging (Individuals); Age Differences; Individual Characteristics
    • الرقم المعرف:
      10.1002/bimj.201900094
    • نبذة مختصرة :
      We analyze adolescent BMI and middle-age systolic blood pressure (SBP) repeatedly measured on women enrolled in the Fels longitudinal study (FLS) between 1929 and 2010 to address three questions: Do adolescent-specific growth rates in BMI and menarche affect middle-age SBP? Do they moderate the aging effect on middle-age SBP? Have the effects changed over historical time? To address the questions, we propose analyzing a growth curve model (GCM) that controls for age, birth-year cohort and historical time. However, several complications in the data make the GCM analysis non-standard. First, the person-specific adolescent BMI and middle-age SBP trajectories are unobservable. Second, missing data are substantial on BMI, SBP and menarche. Finally, modeling the latent trajectories for BMI and SBP, repeatedly measured on two distinct sets of unbalanced time points, are computationally intensive. We adopt a bivariate GCM for BMI and SBP with correlated random coefficients. To efficiently handle missing values of BMI, SBP and menarche assumed missing at random, we estimate their joint distribution by maximum likelihood via the EM algorithm where the correlated random coefficients and menarche are multivariate normal. The estimated distribution will be transformed to the desired GCM for SBP that includes the random coefficients of BMI and menarche as covariates. We demonstrate unbiased estimation by simulation. We find that adolescent growth rates in BMI and menarche are positively associated with and moderate the aging effect on SBP in middle age, controlling for age, cohort and historical time, but the effect sizes are at most modest. The aging effect is significant on SBP, controlling for cohort and historical time, but not vice versa. [This paper was published in "Biometrical Journal" v62 n7 p1702-1716 2020.]
    • نبذة مختصرة :
      As Provided
    • IES Funded:
      Yes
    • الموضوع:
      2021
    • الرقم المعرف:
      ED609907