Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Bacterial Adhesion*; Cytoskeletal Proteins/*metabolism ; Laminin/*metabolism ; Membrane Glycoproteins/*metabolism ; Mycobacterium leprae/*metabolism ; Schwann Cells/*microbiology; Animals ; Binding Sites ; Calcium/physiology ; Cell Line, Transformed ; Cells, Cultured ; Cytoskeletal Proteins/pharmacology ; Dystroglycans ; Edetic Acid/pharmacology ; Glycosylation ; Humans ; Laminin/chemistry ; Membrane Glycoproteins/pharmacology ; Peripheral Nerves/chemistry ; Rats ; Receptors, Laminin/metabolism ; Recombinant Fusion Proteins/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Schwann Cells/metabolism

alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.

Comment in: Science. 1998 Dec 11;282(5396):1999-2000. doi: 10.1126/science.282.5396.1999. (PMID: 9874652)

0 (Cytoskeletal Proteins)
0 (DAG1 protein, human)
0 (Laminin)
0 (Membrane Glycoproteins)
0 (Receptors, Laminin)
0 (Recombinant Fusion Proteins)
0 (Recombinant Proteins)
146888-27-9 (Dystroglycans)
9G34HU7RV0 (Edetic Acid)
SY7Q814VUP (Calcium)

Date Created: 19981216 Date Completed: 19981224 Latest Revision: 20190619

20250114

10.1126/science.282.5396.2076

9851927