Measurement of serum and synovial fluid keratan sulphate and antibody to collagen type II in equine osteoarthritis.

Publisher: Verlag Paul Parey Country of Publication: Germany NLM ID: 0331323 Publication Model: Print Cited Medium: Print ISSN: 0514-7158 (Print) Linking ISSN: 05147158 NLM ISO Abbreviation: Zentralbl Veterinarmed A Subsets: MEDLINE

Publication: Berlin : Verlag Paul Parey
Original Publication: Berlin, Verlag Paul Parey.

Autoantibodies/*analysis ; Collagen/*immunology ; Horse Diseases/*physiopathology ; Keratan Sulfate/*analysis ; Osteoarthritis/*veterinary ; Synovial Fluid/*chemistry; Animals ; Autoantibodies/blood ; Horse Diseases/blood ; Horses ; Keratan Sulfate/blood ; Osteoarthritis/blood ; Osteoarthritis/physiopathology ; Synovial Fluid/immunology

Keratan sulphate (KS) concentration and anticollagen type II antibody levels were measured in the serum and synovial fluid (SF) of clinically normal horses and horses with osteoarthritis (OA). Serum KS in OA was significantly higher than that in normal horses, while no significant difference was found in KS levels of SF between normal and OA. Assays of antibody to collagen type II showed no significant increase in sera and SF of OA. It was suggested that levels of serum KS would be of value in the pathological detection of OA in the joint, although there was no evidence that the measurable autoimmunity to collagen antigens would reflect the process of OA.

0 (Autoantibodies)
9007-34-5 (Collagen)
9056-36-4 (Keratan Sulfate)

Date Created: 19981205 Date Completed: 19990119 Latest Revision: 20190915

20250114

10.1111/j.1439-0442.1998.tb00854.x

9838863