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Hemophilia growth and development study: relationships between neuropsychological, neurological, and MRI findings at baseline.

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  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 7801773 Publication Model: Print Cited Medium: Print ISSN: 0146-8693 (Print) Linking ISSN: 01468693 NLM ISO Abbreviation: J Pediatr Psychol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 1998- : Cary, NC : Oxford University Press
      Original Publication: Washington, Society of Pediatric Psychology.
    • الموضوع:
      Developmental Disabilities/*epidemiology ; HIV Infections/*complications ; Hemophilia A/*complications; Adolescent ; Child ; Humans ; Least-Squares Analysis ; Magnetic Resonance Imaging ; Male ; Neurologic Examination ; United States/epidemiology
    • نبذة مختصرة :
      Objective: To determine the effects of human immunodeficiency virus (HIV) infection on children's development by identifying neurological and environmental variables associated with neuropsychological measures of cognitive development in HIV-seronegative (HIV-) and HIV-seropositive (HIV+)children and adolescents with hemophilia.
      Methods: Participants (N = 298; 60% HIV+) were males ages 7-19 years enrolled in the Hemophilia Growth and Development Study (HGDS). Least squares modeling was used to determine whether there was a difference at baseline in mean neuropsychological test scores by HIV status, age, and neurological baseline findings, adjusting for selected environmental and medical history variables.
      Results: The participants were within age expectations for general intelligence. Variables associated with lowered neuropsychological performance included academic problems, coordination and/or gait abnormalities, parents' education, and previous head trauma.
      Conclusions: Hemophilia-related morbidity has a subtle adverse influence on cognitive performance. HIV infection was not associated with neuropsychological dysfunction in this group even when MRI abnormalities were present.
    • Grant Information:
      MCJ-060570 United States PHS HHS; MO1-RR06020 United States RR NCRR NIH HHS; N01-HD-4-3200 United States HD NICHD NIH HHS; etc.
    • الموضوع:
      Date Created: 19980502 Date Completed: 19980520 Latest Revision: 20190512
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1093/jpepsy/23.1.45
    • الرقم المعرف:
      9564128