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53BP1, a Medicator of the DNA Damage Checkpoint.
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- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
53BP1 binds to the tumor suppressor protein p53 and has a potential role in DNA damage responses. We used small interfering RNA (siRNA) directed against 53BP1 in mammalian cells to demonstrate that 53BP1 is a key transducer of the DNA damage checkpoint signal. 53BP1 was required for p53 accumulation, G[sub 2]-M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation. 53BP1 played a partially redundant role in phosphorylation of the downstream checkpoint effector proteins Brca 1 and Chk2 but was required for the formation of Brcal foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
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