The effect of tranexamic acid on pregnancy outcome and vaginal postparturition hemodynamics.

Background: Tranexamic acid, as an anti-fibrinolytic agent, has been shown to reduce bleeding, but its use has been limited in the scope of vaginal delivery. The purpose of this study was to examine the effect of tranexamic acid on pregnancy outcome and vaginal post-parturition hemodynamics. Materials and Methods: In a randomized, double-blind clinical trial, 200 primgravida pregnants were divided into the two groups (case and control). The case group received IV tranexamic acid immediately post-parturition and the control group IV glucose 5%. Hemoglobin (Hb) on admission and 24 hours post-parturition were measured and Hb level drop more than 10% was considered as postpartum hemorrhage. The Hb status was evaluated through measuring blood pressure and heart rate. The pregnancy outcome measures (e.g. changes in Hb level, need for the additional uterotonic drugs, blood transfusion and surgery) were evaluated. Results: There was a significant difference between the two groups in Hb level drop within the first 24 hours post-parturition. Moreover, no severe bleeding, blood transfusion and misoprostol administration were reported in the case group, but 4 cases in the control group. Conclusion: Tranexamic acid administration can effectively reduce post-partum bleeding and therefore prevent a further decrease in maternal Hb levels. [ABSTRACT FROM AUTHOR]