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Associations of in Utero Exposure to Perfluorinated Alkyl Acids with Human Semen Quality and Reproductive Hormones in Adult Men.
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- المؤلفون: Vested, Anne1 ; Ramlau-Hansen, Cecilia Høst1,2; Olsen, Sjurdur Frodi3; Bonde, Jens Peter4; Kristensen, Susanne Lund1; Halldorsson, Thorhallur Ingi3,5; Becher, Georg6; Haug, Line Småstuen6; Ernst, Emil Hagen7; Toft, Gunnar1
- المصدر:
Environmental Health Perspectives. Apr2013, Vol. 121 Issue 4, p453-458. 6p. 1 Diagram, 3 Charts.
- الموضوع:
- معلومة اضافية
- الموضوع:
- نبذة مختصرة :
Background: Perfluorinated alkyl acids (PFAAs), persistent chemicals with unique water-, dirt-, and oil-repellent properties, are suspected of having endocrine-disrupting activity. The PFAA compounds perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are found globally in humans; because they readily cross the placental barrier, in utero exposure may be a cause for concern. Objectives: We investigated whether in utero exposure to PFOA and PFOS affects semen quality, testicular volume, and reproductive hormone levels. Methods: We recruited 169 male offspring (19-21 years of age) from a pregnancy cohort established in Aarhus, Denmark, in 1988-1989, corresponding to 37.6% of the eligible sons. Each man provided a semen sample and a blood sample. Semen samples were analyzed for sperm concentration, total sperm count, motility, and morphology, and blood samples were used to measure reproductive hormones. As a proxy for in utero exposure, PFOA and PFOS were measured in maternal blood samples from pregnancy week 30. Results: Multivariable linear regression analysis suggested that in utero exposure to PFOA was associated with lower adjusted sperm concentration (ptrend = 0.01) and total sperm count (ptrend = 0.001) and with higher adjusted levels of luteinizing hormone (ptrend = 0.03) and follicle-stimulating hormone (ptrend = 0.01). PFOS did not appear to be associated with any of the outcomes assessed, before or after adjustment. Conclusions: The results suggest that in utero exposure to PFOA may affect adult human male semen quality and reproductive hormone levels. [ABSTRACT FROM AUTHOR]
- نبذة مختصرة :
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