Novelty and familiarity activations in PET studies of memory encoding and retrieval.

Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Print ISSN: 1047-3211 (Print) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE

Original Publication: New York, NY : Oxford University Press, c1991-

Brain/*diagnostic imaging ; Cerebrovascular Circulation/*physiology ; Memory/*physiology; Brain/physiology ; Humans ; Male ; Photic Stimulation ; Task Performance and Analysis ; Tomography, Emission-Computed

Nine young right-handed men viewed colored pictures of people, scenes, and landscapes. Then, 24 hr later while undergoing PET scanning, they viewed previously studied (OLD) pictures in one type of scan, and previously not seen (NEW) pictures in another. The OLD-NEW subtraction of PET images indicates familiarity, and the NEW-OLD indicates novelty. Familiarity activations, signalling aspects of retrieval, were observed in the left and right frontal areas, and posterior regions bilaterally. Novelty activations were in the right limbic regions, and bilaterally in temporal and parietal regions, including area 37. These latter activations were located similarly to novelty activations in previous PET studies using visual words and auditory sentences, suggesting the existence of brain regions specializing in transmodal novelty assessment. The effects of novelty are seen both behaviorally and in replicable patterns of cortical and subcortical activation. We propose a 'novelty/encoding hypothesis': (1) novelty assessment represents an early stage of long-term memory encoding; (2) elaborate, meaning-based encoding processes operate on the incoming information to the extent of its novelty, and therefore (3) the probability of long-term storage of information varies directly with the novelty of the information.

Date Created: 19960101 Date Completed: 19961119 Latest Revision: 20190512

20221213

10.1093/cercor/6.1.71

8670640