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A note on circular-dichroic-constrained prediction of protein secondary structure.

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  • المؤلفون: Galat A;Galat A
  • المصدر:
    European journal of biochemistry [Eur J Biochem] 1996 Mar 01; Vol. 236 (2), pp. 428-35.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 0107600 Publication Model: Print Cited Medium: Print ISSN: 0014-2956 (Print) Linking ISSN: 00142956 NLM ISO Abbreviation: Eur J Biochem Subsets: MEDLINE
    • بيانات النشر:
      Publication: -2004: Oxford, UK : Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
      Original Publication: Berlin, New York, Springer.
    • الموضوع:
      Circular Dichroism* ; Cyclophilins*; Carrier Proteins/*chemistry ; DNA-Binding Proteins/*chemistry ; Heat-Shock Proteins/*chemistry; Amino Acid Isomerases/chemistry ; Amino Acid Sequence ; Animals ; Bacterial Proteins/chemistry ; Cattle ; Fungal Proteins/chemistry ; Humans ; Molecular Sequence Data ; Peptidylprolyl Isomerase ; Protein Structure, Secondary ; Sequence Alignment ; Tacrolimus/chemistry ; Tacrolimus Binding Proteins
    • نبذة مختصرة :
      Circular dichroic (CD) spectra of bovine immunosuppressant binding proteins FKBP12 and FKBP25, and cyclophilins (peptidylprolyl isomerases) A (bCyP-18) and B(bCyP-20), the immunophilins which selectively bind the clinically useful immunosuppressants FK506, rapamycin and cyclosporin A, respectively, were analysed using the singular-value-decomposition algorithm augmented by a simplified variable selection method. The differences between the CD-estimated values of alpha-helix, beta-structure and beta-turn and those predicted by the Chou-Fasman algorithm were minimized using the CD data as constraints of an algorithm which utilizes the method of hierarchical updating of quasi-equipotential peptide segments of the Chou-Fasman prediction. The method allows one to correct the Chou-Fasman prediction of secondary structures in globular proteins.
    • الرقم المعرف:
      0 (Bacterial Proteins)
      0 (Carrier Proteins)
      0 (DNA-Binding Proteins)
      0 (Fungal Proteins)
      0 (Heat-Shock Proteins)
      137497-17-7 (cyclophilin B)
      147478-69-1 (FKBP3 protein, human)
      EC 5.1.1.- (Amino Acid Isomerases)
      EC 5.2.1.- (Cyclophilins)
      EC 5.2.1.- (Tacrolimus Binding Proteins)
      EC 5.2.1.8 (Peptidylprolyl Isomerase)
      WM0HAQ4WNM (Tacrolimus)
    • الموضوع:
      Date Created: 19960301 Date Completed: 19960603 Latest Revision: 20190620
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1111/j.1432-1033.1996.00428.x
    • الرقم المعرف:
      8612612