Assessment of environmental and genetic factors in the etiology of childhood cancers: the Childrens Cancer Group epidemiology program.

Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE

Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.

Neoplasms/*etiology ; Neoplasms/*genetics; Acute Disease ; Adolescent ; Child ; Environmental Exposure ; Epidemiologic Methods ; Hodgkin Disease/etiology ; Humans ; Leukemia, Myeloid/etiology ; Neoplasms/epidemiology ; Neuroblastoma/etiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/etiology

The occurrence of cancer during childhood represents one of the leading causes of death within the pediatric and adolescent age group. It is estimated that approximately 8000 children will be diagnosed annually with cancer in the United States. Epidemiologic research addressing the etiology of childhood cancer has been limited because of the difficulties in identifying a sufficiently large study population. Moreover, the use of retrospectively ascertained childhood cancer cases in epidemiologic investigations has restricted the incorporation of biological and clinical parameters. The Childrens Cancer Group has developed an active program in epidemiologic research, with over a decade of experience demonstrating the feasibility and strengths of conducting analytic epidemiologic studies within a cooperative clinical trials network. The availability of detailed clinical and biologic data on cases diagnosed within the cooperative group facilitates the transfer of state-of-the-art technology to epidemiologic research.

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Date Created: 19950901 Date Completed: 19960220 Latest Revision: 20181113

20240829

PMC1518916

10.1289/ehp.95103s6111

8549456