Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- المؤلفون: Pauline Persson, Louise Jeanette1 ; Aanerud, Marianne1; Hiemstra, Pieter Sicco2; Hardie, Jon Andrew1,3; Bakke, Per Sigvald3; Lind Eagan, Tomas Mikal1,3
- المصدر:
PLoS ONE. Jun2012, Vol. 7 Issue 6, p1-8. 8p.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
Introduction: COPD patients may be at increased risk for vitamin D (25(OH)D) deficiency, but risk factors for deficiency among COPD patients have not been extensively reported. Methods: Serum 25(OH)D levels were measured by liquid chromatography double mass spectrometry in subjects aged 40- 76 years from Western Norway, including 433 COPD patients (GOLD stage II-IV) and 325 controls. Levels <20 ng/mL defined deficiency. Season, sex, age, body mass index (BMI), smoking, GOLD stage, exacerbation frequency, arterial oxygen tension (PaO2), respiratory symptoms, depression (CES-D score≥16), comorbidities (Charlson score), treatment for osteoporosis, use of inhaled steroids, and total white blood count were examined for associations with 25(OH)D in both linear and logistic regression models. Results: COPD patients had an increased risk for vitamin D deficiency compared to controls after adjustment for seasonality, age, smoking and BMI. Variables associated with lower 25(OH)D levels in COPD patients were obesity ( =-6.63), current smoking ( =-4.02), GOLD stage III- IV ( =-4.71, =-5.64), and depression ( =-3.29). Summertime decreased the risk of vitamin D deficiency (OR = 0.22). Conclusion: COPD was associated with an increased risk of vitamin D deficiency, and important disease characteristics were significantly related to 25(OH)D levels. [ABSTRACT FROM AUTHOR]
No Comments.