Item request has been placed!
×
Item request cannot be made.
×
Processing Request
The molecular determinants of CD8 co-receptor function.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- المؤلفون: Cole, David K.1; Laugel, Bruno1; Clement, Mathew1; Price, David A.1; Wooldridge, Linda1; Sewell, Andrew K.1
- المصدر:
Immunology. Oct2012, Vol. 137 Issue 2, p139-148. 10p. 3 Color Photographs, 1 Chart, 3 Graphs.
- الموضوع:
- معلومة اضافية
- نبذة مختصرة :
CD8+ T cells respond to signals mediated through a specific interaction between the T-cell receptor ( TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I ( MHCI) molecule. The CD8 glycoprotein 'co-receives' antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands. [ABSTRACT FROM AUTHOR]
No Comments.