Characterizing the Disintegration Rate of Hypromellose Films and Capsules.

BIOPOLYMERS; BIOAVAILABILITY; BIOMOLECULES; BIOCHEMISTRY; DISINTEGRATION of microorganisms

The disintegration properties of hypromellose (HPMC) biopolymers directly affect the release profile and bioavailability of APIs. While HPMC is generally well studied, the disintegration rate of HPMC without gelling agents or other additives had not yet been researched. In this article, the authors investigate the disintegration rate of HPMC and gelatin films as a function of film thickness and media temperature and propose a mechanism for HPMC disintegration. [ABSTRACT FROM AUTHOR]

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