Quantitative immunohistochemistry of immunoglobulin- and J-chain-producing cells in human parotid and submandibular salivary glands.

Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print Cited Medium: Print ISSN: 0019-2805 (Print) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE

Original Publication: Oxford : Blackwell Scientific Publications

Immunoglobulin J-Chains/*analysis ; Immunoglobulins/*analysis ; Parotid Gland/*immunology ; Submandibular Gland/*immunology; Adult ; Aged ; Antibody-Producing Cells ; Dysgammaglobulinemia/immunology ; Female ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin A ; Male ; Middle Aged

Ig-producing cells were quantified by paired immunohistochemical staining in saline-extracted and paraffin-embedded normal tissue specimens from human parotid (ten) and submandibular (seven) salivary glands. The density of such cells (number/mm2 of 6 micron thick tissue section) was significantly higher in the submandibular than in the parotid gland (P less than 0.005), but the Ig-class distribution was fairly similar. The mean percentage class ratios for IgG, IgA, IgM and IgD cells in the parotid were 4.5:86.5:5.9:3.1, and in the submandibular gland 3.7:86.9:7.9:1.6. In the parotid gland of a patient with selective IgA deficiency the same class ratios were 27:0:20:53. Thus, the IgA cells were especially replaced by IgD cells. In normal glands most of the IgA (80-93%), IgM (99-100%) and IgD cells (81-95%) were J-chain-positive; this was likewise true for a substantial proportion of the IgG cells (32-46%). Of additional interest was the finding that in the IgA-deficient parotid gland, 99% of the numerous IgD cells and 86% of the increased number of IgG cells contained cytoplasmic J chain. IgE-producing cells were virtually absent from the IgA-deficient as well as from the normal salivary glands.

Gastroenterology. 1966 Sep;51(3):305-16. (PMID: 4161535)
Lab Invest. 1967 Jan;16(1):112-23. (PMID: 4164458)
Science. 1968 May 17;160(3829):789-91. (PMID: 4171541)
J Immunol. 1968 Apr;100(4):706-17. (PMID: 4172129)
Immunology. 1968 Jun;14(6):809-17. (PMID: 4173674)
J Lab Clin Med. 1970 May;75(5):856-62. (PMID: 5442851)
Clin Exp Immunol. 1971 Jan;8(1):69-85. (PMID: 4099989)
Arch Oral Biol. 1971 Jul;16(7):781-9. (PMID: 4104226)
Cancer. 1973 Jun;31(6):1408-13. (PMID: 4709955)
Nat New Biol. 1973 May 30;243(126):142-3. (PMID: 4578172)
Scand J Immunol. 1973;2(4):333-48. (PMID: 4129417)
Scand J Immunol. 1973;2(3):273-90. (PMID: 4797751)
Immunology. 1974 Jun;26(6):1101-14. (PMID: 4604796)
Adv Exp Med Biol. 1974;45(0):87-97. (PMID: 4137572)
Immunol Commun. 1974;3(5):427-38. (PMID: 4214759)
Cancer. 1975 Apr;35(4):1154-62. (PMID: 803867)
Arch Oral Biol. 1975 Nov;20(11):701-4. (PMID: 1061519)
Clin Exp Immunol. 1975 Nov;22(2):197-209. (PMID: 1082398)
Caries Res. 1976;10(3):165-77. (PMID: 1063599)
Science. 1976 Jun 18;192(4245):1238-40. (PMID: 1273589)
Scand J Immunol. 1976;5(4):411-9. (PMID: 821140)
Clin Exp Immunol. 1976 Jul;25(1):50-8. (PMID: 62630)
Clin Exp Immunol. 1976 Jul;25(1):59-66. (PMID: 62631)
Immunochemistry. 1977 Mar;14(3):179-88. (PMID: 405313)
Adv Cancer Res. 1977;25:95-148. (PMID: 68659)
Clin Immunol Immunopathol. 1977 Nov;8(3):475-86. (PMID: 410569)
Int J Cancer. 1977 Dec 15;20(6):881-6. (PMID: 201574)
Ciba Found Symp. 1977 Apr 26-28;(46):77-113. (PMID: 416937)
Clin Exp Immunol. 1978 Mar;31(3):367-81. (PMID: 350457)
Scand J Immunol. 1978;8(1):39-52. (PMID: 81514)
Int J Cancer. 1979 Feb;23(2):165-73. (PMID: 367974)
J Immunol. 1979 Feb;122(2):503-10. (PMID: 105047)
Adv Exp Med Biol. 1978;107:185-92. (PMID: 742482)
Adv Exp Med Biol. 1978;107:209-17. (PMID: 742483)
Stain Technol. 1963 Mar;38:133-5. (PMID: 14020491)
J Exp Med. 1965 Jan 1;121:101-24. (PMID: 14253478)

0 (Immunoglobulin A)
0 (Immunoglobulin J-Chains)
0 (Immunoglobulins)

Date Created: 19800201 Date Completed: 19800828 Latest Revision: 20181113

20250114

PMC1457971

6769784