Controlled crystallisation during freeze-drying.

The authors discuss the preparation of lipophilic drug nanocrystals by controlled crystallisation during freeze-drying (CCDF). In-line Raman spectroscopy was used to monitor the crystallisation of the drug during freeze-drying to elucidate how the size of the drug crystals could be controlled. A three-way nozzle was used to create a spray freeze- drying process suitable for large-scale production. [ABSTRACT FROM AUTHOR]

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