Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

TUMORI ENDOCRINE GASTROENTEROPANCREATICE. STUDII MORFOPATOLOGICE ŞI IMUNOHISTOCHIMICE.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Alternate Title:
      Gastroenteropancreatic endocrine tumors. Pathomorphological and immunohistochemical studies.
    • نبذة مختصرة :
      Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare neoplasms that develop from the neuroendocrine cells of the gastroenteropancreatic tract (at least 15 types of cells), characterized by a certain (neuroendocrine) phenotype. They are capable of producing different hormones that can be recognized by clinical consequences and various measurement techniques. The study included 100 patients with neuroendocrine tumors, diagnosed by the histological and immunohistochemical pattern (synaptophysin, chromogranins, neuron-specific enolase, vimentin). Epidemiological data, pathomorphological aspects (location, degree of differentiation, benign tumors or carcinomas, local or vascular invasion, presence of metastases), the functional type (presence of hormonal syndrome) or non-functional type were analyzed. In correlation with clinical data, hormone secreting GEP-NETs (in our study carcinoid tumors, insulinomas, glucagonomas) were evaluated. [ABSTRACT FROM AUTHOR]
    • نبذة مختصرة :
      Tumorile neuroendocrine gastroenteropancreatice (GEP-NETs) sunt neoplazii rare ce se dezvoltă din celulele neuroendocrine ale tractului gastroenteropancreatic (cel puţin 15 tipuri de celule) caracterizate printr-un anumit fenotip (neuroendocrin). Ele sunt capabile de a produce hormoni diferiţi ce pot fi recunoscuţi prin consecinţele clinice şi diferite tehnici de determinare. S-au luat în studiu 100 de pacienţi cu tumori neuroendocrine diagnosticaţi prin pattern-ul histologic şi imunohistochimic (synaptophysin, chromogranine, enolaza neurospecifică, vimentin). S-au analizat câteva date de epidemiologie, aspecte morfopatologice (localizare, gradul de diferenţiere, benigne sau carcinoame, invazia locală sau vasculară, prezenţa metastazelor), tipul funcţional (sindrom hormonal prezent) sau nefuncţional. Corelate cu datele clinice s-au evaluat GEP-NETs secretante (în studiul nostru tumori carcinoide, insulinomul glucagonomul). [ABSTRACT FROM AUTHOR]