Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effects of subchronic exposure to meloxicam on some hematological, biochemical and liver histopathological parameters in rats.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • نبذة مختصرة :
      This experiment was conducted to study the effects of sub chronic exposure of Meloxicam in male albino rats by measuring Hematological, Biochemical and Histopathological changes of Livers in (18) rats divided equally into two treatment groups, T1 which dosed with 0.2 mg/KG.BW as therapeutic dose and T2 which dosed with 0.6 mg/KG.BW as three fold dose, while the other (6) animals considered as control group dosed with distilled water by stomach tube for duration (2) months. Evaluation of complete blood picture (RBCs and WBCs counts, differential WBCs count, platelets count, PCV and Hb), clotting time and serum level of liver enzyme function, Blood urea (BU) and histopathological examination of liver was performed at the end of experiment. The results revealed significant decrease in platelets count (P⩽0.01) of both treated groups and significant increase clotting time of T2 group (P⩽0.01) in comparison with the T1 group and control one. The results of differential count of white blood cells registered significant decrease(P⩽0.05) in neutrophils and significant increases (P⩽0.01) in Monocytes and Lymphocytes of both treated groups in comparison with control group. The results of serum level of liver enzymes function revealed only significant increase (P⩽0.01) in AST of both treated groups in comparison with the control one, while the histopathological study of liver showed lesions was vary between vasodilatation, vasocongestion and necrosis, karryorrhexis of hepatocytes. [ABSTRACT FROM AUTHOR]
    • نبذة مختصرة :
      Copyright of Iraqi Journal of Veterinary Sciences is the property of University of Mosul, College of Veterinary Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)