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Outcome of HIV patients on ART during the war and siege in a tertiary hospital in Northern Ethiopia: a cross-sectional study.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      HIV Infections*/drug therapy ; HIV Infections*/virology ; HIV Infections*/epidemiology ; Tertiary Care Centers* ; Viral Load* ; Anti-HIV Agents*/therapeutic use; Humans ; Ethiopia/epidemiology ; Male ; Adult ; Cross-Sectional Studies ; Female ; Middle Aged ; CD4 Lymphocyte Count ; Treatment Outcome ; Young Adult
    • نبذة مختصرة :
      Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: Ethical Clearance was obtained from the Institutional Review Board of College of Health Science, Mekelle University with a reference number of 2018/2022. All data were fully anonymized before we accessed them and the Institutional Review Board of College of Health Science waived the requirement for informed consent. Confidentiality was maintained at all levels of the study and all the information obtained was used for this study only. We confirm that all the methods were carried out in accordance with relevant Institutional guidelines and regulations.
      The war and siege in Tigray, Ethiopia, have devastated the region's health system, critically impacting care for people living with HIV. This study aimed to assess the outcomes and factors affecting HIV patients during this crisis. An independent, repeated cross-sectional study was conducted at Ayder Comprehensive Specialized Hospital between October and November 2022. Data from prewar and during the war periods were analyzed using descriptive statistics and logistic regression. Among 440 participants (mean ages: 39 prewar and 41.2 during war), poor outcomes increased significantly during the war (28.6% prewar vs. 54.5% during war, p < 0.001). ART drug availability dropped by 68.8%, while only 10.6% and 30.7% accessed IPT and CPT, respectively. Services like CD4 and viral load determinations were severely disrupted (p < 0.001), with frequent ART switches and more missed appointments. Prewar factors associated with poor outcomes included severe malnutrition (AOR 3.98; 95% CI 1.04-15.22) and viral load > 1000 copies (AOR 6.68; 95% CI 2.91-15.32). During the crisis, significant factors included travel from distant areas (AOR 2.56; 95% CI 1.14-5.74), CD4 count > 200 cells/ml (AOR 0.27; 95% CI 0.08-0.97). The war and siege in Tigray significantly worsened HIV outcomes by disrupting care services and limiting access to essential treatments.
      (© 2025. The Author(s).)
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    • Contributed Indexing:
      Keywords: ART; HIV/AIDS; Outcome; War
    • الرقم المعرف:
      0 (Anti-HIV Agents)
    • الموضوع:
      Date Created: 20250221 Date Completed: 20250221 Latest Revision: 20250224
    • الموضوع:
      20250225
    • الرقم المعرف:
      PMC11845719
    • الرقم المعرف:
      10.1038/s41598-025-90848-w
    • الرقم المعرف:
      39984629