Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Impact of Maternal Macronutrient Intake on Large for Gestational Age Neonates' Risk Among Women with Gestational Diabetes Mellitus: Results from the Greek BORN2020 Cohort.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • الموضوع:
      Diabetes, Gestational*/epidemiology ; Body Mass Index* ; Fetal Macrosomia*/epidemiology ; Fetal Macrosomia*/etiology; Humans ; Female ; Pregnancy ; Greece/epidemiology ; Adult ; Infant, Newborn ; Risk Factors ; Maternal Nutritional Physiological Phenomena ; Cohort Studies ; Nutrients/administration & dosage ; Dietary Fiber/administration & dosage ; Birth Weight ; Diet ; Gestational Age
    • نبذة مختصرة :
      Background/objectives: The effect of maternal macronutrient composition on the risk of large for gestational age (LGA) neonates among women with gestational diabetes mellitus (GDM) is not well understood. This study aimed to investigate these associations in a pregnant cohort in Northern Greece, considering both pre-pregnancy and early pregnancy dietary intake, and stratifying women by pre-pregnancy body mass index (BMI).
      Methods: From a total of 797 eligible pregnant women, the 117 (14.7%) who developed GDM (and thus were included in the study) completed the validated Food Frequency Questionnaires (FFQs). Macronutrient intake was assessed for the six months before pregnancy and until mid-gestation, prior to the oral glucose tolerance test. Data were compared with European Food Safety Authority (EFSA) guidelines, and participants were stratified by pre-pregnancy BMI (normal vs. overweight/obese). Multivariate logistic regression was used to estimate adjusted odds ratios (aORs) for LGA risk.
      Results: In normal-BMI women with GDM, higher dietary fiber (aOR = 1.39) and vegetable protein (aOR = 1.61) intake before pregnancy were both significantly associated with an increased risk of LGA. During early pregnancy, the elevated risk from vegetable protein persisted (aOR = 1.51). Among overweight/obese women, no significant pre-pregnancy associations were observed. However, during early pregnancy, a higher percentage of total carbohydrate intake was linked to increased LGA risk (aOR = 1.11), while maintaining saturated fatty acids "as low as possible" reduced the odds of LGA (aOR = 0.71). Elevated vegetable protein intake also increased LGA risk (aOR = 1.61).
      Conclusions: Maternal macronutrient intake prior to and during early pregnancy may influence LGA risk in GDM, with distinct patterns according to pre-pregnancy BMI. These findings underscore the importance of tailoring dietary recommendations-especially regarding fiber, vegetable protein, carbohydrates, and saturated fat-to mitigate the risk of LGA in women with GDM.
    • References:
      Nutrients. 2024 Jan 30;16(3):. (PMID: 38337683)
      Food Nutr Res. 2019 Dec 20;63:. (PMID: 31920469)
      Asia Pac J Clin Nutr. 2017 Mar;26(2):291-297. (PMID: 28244708)
      Biol Reprod. 2013 Oct 24;89(4):96. (PMID: 24006279)
      Nutrients. 2024 Oct 25;16(21):. (PMID: 39519467)
      Nutrition. 2021 Oct;90:111357. (PMID: 34218120)
      Adv Nutr. 2019 Jul 1;10(4):685-695. (PMID: 31041446)
      J Diabetes Complications. 2018 Jul;32(7):635-642. (PMID: 29907325)
      Nutr Rev. 2017 Jan;75(suppl 1):32-50. (PMID: 28049748)
      Nutrients. 2016 Apr 28;8(5):. (PMID: 27136584)
      J Obes Metab Syndr. 2021 Jun 30;30(2):124-131. (PMID: 34053939)
      Lancet. 2018 May 5;391(10132):1842-1852. (PMID: 29673874)
      BMC Pregnancy Childbirth. 2020 Oct 27;20(1):649. (PMID: 33109112)
      Am J Clin Nutr. 2016 Nov;104(5):1416-1423. (PMID: 27733407)
      Eur J Clin Nutr. 2014 Jan;68(1):8-13. (PMID: 24084515)
      J Matern Fetal Neonatal Med. 2023 Dec;36(2):2273216. (PMID: 37904502)
      Am J Obstet Gynecol. 2023 Jun;228(6):756-758.e3. (PMID: 36848986)
      BMJ Open. 2024 Dec 9;14(12):e092888. (PMID: 39653580)
      Proc Nutr Soc. 2015 Nov;74(4):454-9. (PMID: 26264457)
      Eur J Nutr. 2018 Feb;57(1):167-177. (PMID: 27612876)
      Am J Obstet Gynecol. 2010 Jun;202(6):654.e1-6. (PMID: 20510967)
      Nutrients. 2023 Feb 07;15(4):. (PMID: 36839206)
    • Contributed Indexing:
      Keywords: GDM; LGA; carbohydrates; diet; fat; gestational diabetes mellitus; macronutrients; macrosomia; maternal; nutrition; pregnancy; protein
    • الرقم المعرف:
      0 (Dietary Fiber)
    • الموضوع:
      Date Created: 20250125 Date Completed: 20250125 Latest Revision: 20250128
    • الموضوع:
      20250128
    • الرقم المعرف:
      PMC11767984
    • الرقم المعرف:
      10.3390/nu17020269
    • الرقم المعرف:
      39861399