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Influence of Apis mellifera syriaca Bee Venom on Nociception and Inflammatory Cytokine Profiles in Experimental Hyperalgesia.

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  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel : MDPI
    • الموضوع:
      Bee Venoms*/pharmacology ; Bee Venoms*/therapeutic use ; Hyperalgesia*/drug therapy ; Hyperalgesia*/chemically induced ; Hyperalgesia*/metabolism ; Cytokines*/metabolism ; Nociception*/drug effects ; Anti-Inflammatory Agents*/pharmacology ; Anti-Inflammatory Agents*/therapeutic use; Animals ; Male ; Female ; Mice ; Formaldehyde ; Bees ; Disease Models, Animal
    • نبذة مختصرة :
      Hyperalgesia is a condition marked by an abnormal increase in pain sensitivity, often occurring in response to tissue injury, inflammation, or prolonged exposure to certain medications. Inflammatory mediators, such as cytokines IL-1β, IL-6, and TNF-α, play a central role in this process, amplifying pain perception. Developing effective treatments that address the underlying mechanisms of hyperalgesia is an active field of research. Apis mellifera syriaca venom demonstrated potential immunomodulatory activity associated with cytokine release in vivo. Therefore, the aim of this study is to evaluate the effect of Apis mellifera syriaca bee venom ( Ams BV) on pain sensitivity in a formalin-induced hyperalgesia mice model and to evaluate the potential role of cytokines associated with the nociception of pain. The hotplate test, used to measure pain latency, showed that hypersensitivity to pain was induced in formalin-injected male mice only, with no changes in females, suggesting a sex-based response to formalin. When applied, Ams BV reduced pain sensitivity in males, suggesting pain relief potential. At the molecular level, Ams BV was able to reduce pro-inflammatory interleukin IL-4 and cytokine IFN-γ, emphasizing its immunomodulatory potential. Interestingly, the venom restored anti-inflammatory IL-10 levels that were significantly decreased in hyperalgesia males. Together, these findings highlight the therapeutic potential for Ams BV in managing inflammation and reducing pain, particularly hyperalgesia.
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    • Contributed Indexing:
      Keywords: A. mellifera syriaca; bee venom; cytokines; hyperalgesia; immunomodulatory activity; inflammation; pain
    • الرقم المعرف:
      0 (Bee Venoms)
      0 (Cytokines)
      1HG84L3525 (Formaldehyde)
      0 (Anti-Inflammatory Agents)
    • الموضوع:
      Date Created: 20250124 Date Completed: 20250502 Latest Revision: 20250502
    • الموضوع:
      20250503
    • الرقم المعرف:
      PMC11769041
    • الرقم المعرف:
      10.3390/toxins17010018
    • الرقم المعرف:
      39852971