Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy.

Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE

Original Publication: London : BioMed Central, 2003-

Abortion, Habitual*/etiology ; Abortion, Habitual*/therapy ; Obesity*/therapy ; Obesity*/complications; Humans ; Female ; Pregnancy ; Pregnancy Outcome/epidemiology ; Risk Factors

Recurrent spontaneous abortion (RSA), characterized by the loss of two or more pregnancies, impacts approximately 1-2% of couples and poses a significant challenge for individuals of childbearing age. The precise mechanisms underlying RSA remain incompletely understood. Concurrently, the global prevalence of obesity is on the rise, with obesity being closely associated with female reproductive disorders and infertility. This study initially examines the pathways through which obesity contributes to RSA, encompassing factors such as embryonic euploid miscarriage, endometrial development, immune function, among others. Furthermore, adipokines and the fat mass and obesity-related (FTO) are identified as potential contributors to RSA. The study also explores the enhancement of pregnancy outcomes through various weight management strategies, with a particular focus on the roles of dietary interventions, physical activity, and weight control during pregnancy. Obesity is closely related to RSA in multiple aspects. Additional clinical prospective and experimental studies are required to explore its precise pathogenesis. Through this review, we aim to provide strategies for improvement and treatment approaches for RSA related to obesity. Through this review, we suggest potential clinical management strategies and research avenues aimed at offering enhancements and therapeutic insights for miscarriages linked to obesity and its associated risk factors.
Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2025. The Author(s).)

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2022ZG282 Undergraduate education quality construction comprehensive reform project; 2022ZG282 Undergraduate education quality construction comprehensive reform project; 82071655 National Natural Science Foundation of China; 82071655 National Natural Science Foundation of China; JCRCZN-2022-016 cross-innovation talent project in Renmin Hospital of Wuhan University

Keywords: Body mass index; Endometrium; Immune imbalance; Obesity; Oocytes; Recurrent spontaneous abortion; Weight management

Date Created: 20250123 Date Completed: 20250123 Latest Revision: 20250129

20250129

PMC11752768

10.1186/s12958-024-01326-3

39844265