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From Tea to Functional Foods: Exploring Caryopteris mongolica Bunge for Anti-Rheumatoid Arthritis and Unraveling Its Potential Mechanisms.

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  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • الموضوع:
      Rats, Sprague-Dawley* ; Arthritis, Rheumatoid*/drug therapy ; Arthritis, Experimental*/drug therapy ; Plant Extracts*/pharmacology ; Functional Food* ; Anti-Inflammatory Agents*/pharmacology; Animals ; Female ; Rats ; Molecular Docking Simulation ; Tea/chemistry ; Network Pharmacology ; Signal Transduction/drug effects
    • نبذة مختصرة :
      Background: Caryopteris mongolica Bunge (CM) shows promising potential for managing rheumatoid arthritis (RA) and digestive disorders, attributed to its rich content of bioactive compounds such as polyphenols and flavonoids. Despite its common use in herbal tea, the specific mechanisms underlying CM's anti-inflammatory and joint-protective effects remain unclear, limiting its development as a functional food. This study investigated the effects of aqueous CM extract on RA in collagen-induced arthritis (CIA) rats and explored the underlying mechanisms.
      Methods: Forty-eight female Sprague-Dawley rats were randomly assigned to six groups ( n = 8): normal control, CIA model, methotrexate (MTX), and CM high-, middle-, and low-dose groups. Anti-inflammatory and joint-protective effects were evaluated using biochemical and histological analyses. To elucidate the mechanisms, we applied metabolomics, network pharmacology, and transcriptomics approaches.
      Results: The results demonstrated that CM extract effectively suppressed synovial inflammation in CIA rats, reducing joint degradation. CM's anti-inflammatory effects were mediated through the TNF signaling pathway, modulating glycerophospholipid and amino acid metabolism, including reduced levels of tryptophan, LysoPC, and asparagine. Molecular docking identified scutellarin and apigenin as key bioactive compounds. Additionally, immunofluorescence analysis revealed CM's therapeutic effects via TNF signaling inhibition and suppression of M1 macrophage polarization.
      Conclusions: These findings highlight the therapeutic potential of CM for RA and support its development as a functional food or pharmaceutical product.
    • Grant Information:
      NMGlRT2222 & BR22-13-05 IMAU & Inner Mongolia Autonomous Region University Science and Technology Innovation Team
    • Contributed Indexing:
      Keywords: Caryopteris mongolica Bunge; inflammatory response; mechanism; metabolomics; rheumatoid arthritis; transcriptomics
    • الرقم المعرف:
      0 (Plant Extracts)
      0 (Anti-Inflammatory Agents)
      0 (Tea)
    • الموضوع:
      Date Created: 20250108 Date Completed: 20250108 Latest Revision: 20250108
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.3390/nu16244311
    • الرقم المعرف:
      39770932