Electro-polymerization of modified carbon paste sensor for detecting azithromycin.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Azithromycin*/analysis ; Carbon*/chemistry ; Electrodes* ; Electrochemical Techniques*/methods ; Polymerization*; Limit of Detection ; Dielectric Spectroscopy/methods ; Anti-Bacterial Agents/analysis ; Hydrogen-Ion Concentration ; Humans ; Polymers/chemistry ; Microscopy, Electron, Scanning

Azithromycin (AM) is one of the prescribed drugs in pandemic medication treatment which has paid great attention. We developed in this study a simply modified carbon paste electrode (CPE) to detect AM using poly-threonine (PT). PT or similar polymers are used as carriers to enhance the delivery and effectiveness of AM. The work was characterised via Cyclic Voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). We take into consideration the effects of pH, scan rate, accumulation time, interference, and calibration curve.A very sensitive response to the oxidation of 1.0 mM from AM in phosphate buffer solution (PBS) over a pH range of 5.0 to 10.0 was observed using the developed poly-threonine carbon paste electrode (PTCPE). The impact of different AM concentrations was investigated resulting in a detection limit of 0.32 µM and a quantification limit of 1.07 µM at PBS (pH 7.4). Finally, the recently used electrode realized acceptable sensitivity and consistency for AM detection in pharmaceutical drugs.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2025. The Author(s).)

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Keywords: Antiviral; Azithromycin; COVID-19; Electro-polymerization; L-Threonine

83905-01-5 (Azithromycin)
7440-44-0 (Carbon)
0 (Anti-Bacterial Agents)
0 (Polymers)

Date Created: 20250106 Date Completed: 20250106 Latest Revision: 20250106

20250110

PMC11704252

10.1038/s41598-024-79614-6

39762252