Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

The value of promoter methylation of fibroblast factor 21 (FGF21) in predicting the course of chronic hepatitis B and the occurrence of oxidative stress.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BioMed Central, 2004-
    • الموضوع:
      Hepatitis B, Chronic*/genetics ; Hepatitis B, Chronic*/virology ; Fibroblast Growth Factors*/genetics ; Fibroblast Growth Factors*/blood ; Oxidative Stress* ; Promoter Regions, Genetic* ; DNA Methylation*; Humans ; Male ; Female ; Adult ; Middle Aged ; Leukocytes, Mononuclear/metabolism ; Disease Progression ; Biomarkers/blood ; Hepatitis B virus/genetics ; Young Adult ; Hepatitis B e Antigens/blood ; Hepatitis B e Antigens/genetics
    • نبذة مختصرة :
      Background: Oxidative stress plays a crucial role in the pathogenesis of HBV. This study aimed to investigate the value of fibroblast growth factor 21 (FGF21) promoter methylation in the occurrence and development of chronic hepatitis B (CHB) oxidative stress.
      Methods: A total of 241 participants including 221 patients with CHB and 20 healthy controls (HCs) were recruited. Methylation level of FGF21 promoter in peripheral blood mononuclear cells was quantitatively determined. Enzyme-linked immunosorbent assay was used to assess oxidative stress in CHB patients.
      Results: Our study shows that the FGF21 methylation level was significantly lower in HBeAg-positive CHB patients compared to HBeAg-negative CHB patients and HCs (P < 0.0001). The oxidative stress of HBeAg-positive CHB patients was more severe. Further correlation analysis showed that there was a significant correlation between the methylation level of FGF21 promoter and the occurrence of oxidative stress in CHB patients. In addition, assessment based on FGF21 promoter methylation level proved effective for predicting oxidative stress occurrence and disease progression among CHB patients.
      Conclusion: FGF21 promoter methylation level is an important marker for predicting oxidative stress and disease progression in patients with CHB.
      Competing Interests: Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Medical Ethical Committee of Qilu Hospital of Shandong University. (#KYLL-202306-021-1). Competing interests: The authors declare no competing interests.
      (© 2024. The Author(s).)
    • References:
      Hepatol Int. 2016 Jan;10(1):1-98. (PMID: 26563120)
      Sci Rep. 2016 Jul 29;6:30484. (PMID: 27470139)
      Ther Clin Risk Manag. 2023 Jan 22;19:77-96. (PMID: 36713291)
      Liver Int. 2022 Mar;42(3):663-673. (PMID: 34812573)
      Rev Physiol Biochem Pharmacol. 2018;175:71-102. (PMID: 29728869)
      Nat Rev Gastroenterol Hepatol. 2019 Feb;16(2):106-120. (PMID: 30443019)
      Microorganisms. 2022 Jun 21;10(7):. (PMID: 35888983)
      Viruses. 2021 Feb 26;13(3):. (PMID: 33652619)
      Sci Rep. 2016 Aug 08;6:31026. (PMID: 27498701)
      Rev Endocr Metab Disord. 2019 Mar;20(1):103-114. (PMID: 30879171)
      MMWR Morb Mortal Wkly Rep. 2022 Jul 29;71(30):958-963. (PMID: 35900928)
      Molecules. 2022 May 15;27(10):. (PMID: 35630636)
      Front Med. 2017 Dec;11(4):502-508. (PMID: 29170915)
      Expert Rev Gastroenterol Hepatol. 2021 Sep;15(9):1021-1035. (PMID: 34176419)
      Gastroenterology. 2018 Sep;155(3):629-647. (PMID: 30012333)
      EBioMedicine. 2017 Feb;15:173-183. (PMID: 28041926)
      Viruses. 2022 Feb 21;14(2):. (PMID: 35216027)
      Gastroenterology. 2006 Mar;130(3):678-86. (PMID: 16530509)
      Front Microbiol. 2022 Sep 08;13:975584. (PMID: 36160238)
      Bioinformatics. 2002 Nov;18(11):1427-31. (PMID: 12424112)
      Aliment Pharmacol Ther. 2015 Aug;42(3):319-29. (PMID: 26040771)
      PLoS One. 2011;6(9):e24895. (PMID: 21949781)
      J Hepatol. 2008 Jan;48(1):12-9. (PMID: 18037187)
      Traffic. 2019 Dec;20(12):932-942. (PMID: 31569283)
      Life Sci. 2021 Apr 1;270:119061. (PMID: 33454364)
      Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8. (PMID: 20616029)
      J Endocrinol. 2018 May;237(2):139-152. (PMID: 29615519)
      Cell Metab. 2023 Feb 7;35(2):236-252. (PMID: 36754018)
      World J Gastroenterol. 2014 Jun 28;20(24):7644-52. (PMID: 24976702)
      World J Hepatol. 2023 May 27;15(5):585-608. (PMID: 37305370)
      Sci Rep. 2017 May 10;7(1):1657. (PMID: 28490739)
      Transl Pediatr. 2023 Jun 30;12(6):1121-1129. (PMID: 37427068)
      Endocr Connect. 2020 Aug;9(8):755-768. (PMID: 32688339)
      Int J Mol Med. 2017 Nov;40(5):1477-1485. (PMID: 28949374)
      Hepatology. 2023 Apr 1;77(4):1348-1365. (PMID: 35971873)
      Cytokine Growth Factor Rev. 2017 Dec;38:59-65. (PMID: 28887067)
      Mol Oncol. 2009 Feb;3(1):67-76. (PMID: 19383368)
      Atherosclerosis. 2020 Apr;299:38-44. (PMID: 32220662)
      Expert Opin Med Diagn. 2013 Jul;7(4):313-7. (PMID: 23782039)
      J Pathol. 2021 Feb;253(2):198-208. (PMID: 33125701)
    • Grant Information:
      2021YFC2301801 National Key Research and Development Program of China
    • Contributed Indexing:
      Keywords: FGF21; HBV; Methylation; Oxidative stress
    • الرقم المعرف:
      62031-54-3 (Fibroblast Growth Factors)
      0 (FGF21 protein, human)
      0 (Biomarkers)
      0 (Hepatitis B e Antigens)
      0 (fibroblast growth factor 21)
    • الموضوع:
      Date Created: 20241222 Date Completed: 20241222 Latest Revision: 20250104
    • الموضوع:
      20250104
    • الرقم المعرف:
      PMC11664819
    • الرقم المعرف:
      10.1186/s12985-024-02605-6
    • الرقم المعرف:
      39710689