Resistant starch grafted cerium-sulfasalazine infinite coordination polymers synergistically remold intestinal metabolic microenvironment for inflammatory bowel disease therapy.

Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE

Original Publication: London : BioMed Central, 2003-

Sulfasalazine*/pharmacology ; Sulfasalazine*/chemistry ; Cerium*/chemistry ; Cerium*/pharmacology ; Inflammatory Bowel Diseases*/drug therapy ; Reactive Oxygen Species*/metabolism ; Gastrointestinal Microbiome*/drug effects; Animals ; Mice ; Starch/chemistry ; Polymers/chemistry ; Polymers/pharmacology ; Male ; Resistant Starch/pharmacology ; Humans ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Intestines/drug effects ; Mice, Inbred C57BL

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reactive oxygen species (ROS), increased pro-inflammatory cytokines and disordered intestinal microbes. However, current therapeutic methods usually ignored the interrelation among the pathogenesis, and mainly focused on a single factor, inducing clinical outcomes unsatisfied. Herein, biocompatible infinite coordination polymers of drugs (Ce-SASP-RS ICPs) composed of Ce ions, FDA-approved drug sulfasalazine (SASP) and natural ingredient resistant starch (RS) were developed for synergistic treatment of IBD. The proper Ce ³⁺ /Ce ⁴⁺ ratio in Ce-SASP-RS ICPs can endow them with SOD-like activities, POD-like activities and •OH scavenging ability, which guarantee Ce-SASP-RS ICPs to simultaneously kill bacteria and maintain ROS balance through cascade reactions. Owing to the recovered redox balance microenvironment, SASP in Ce-SASP-RS ICPs can better play their anti-inflammatory function. Moreover, benefitting from the recovered metabolic balance of ROS and inflammatory cytokines in colon, resistant starch can also function better in modifying gut microbiota through generating short-chain fatty acids. Collectively, Ce-SASP-RS ICPs can synergistically restore intestinal metabolic microenvironment through modulating redox balance, attenuating inflammation and modifying intestinal flora. Hence, in view of the mutual influences among IBD pathogenesis, this work presents a synergistic intervention approach for effectively treating IBD.
Competing Interests: Declarations. Ethics approval and consent to participate: Animal studies were approved by the Animal Care and Utilization Committee of Henan University of Science and Technology. Consent for publication: All authors read and agreed to submit the manuscript. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)

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23230042014 Natural Science Foundation of Henan Province; 222102310155 Natural Science Foundation of Henan Province; YJS2022JD50 Postgraduate Education Reform and Quality Improvement Project of Henan Province; U1704150 National Natural Science Foundation of China-Henan Joint Fund; 51902123 National Natural Science Foundation of China

Keywords: Anti-inflammation; Infinite coordination polymers; Inflammatory bowel disease; Intestinal flora regulation; Redox balance

3XC8GUZ6CB (Sulfasalazine)
30K4522N6T (Cerium)
0 (Reactive Oxygen Species)
9005-25-8 (Starch)
0 (Polymers)
0 (Resistant Starch)
0 (Anti-Inflammatory Agents)

Date Created: 20241220 Date Completed: 20241221 Latest Revision: 20250104

20250104

PMC11662453

10.1186/s12951-024-03043-w

39707422